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| 1st(1st leg) | Nacional | - | Atlético Goianiense | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Goianiense | - | Nacional | 3:0 (2:0) | ||
| 1st(1st leg): 02/08/2022 23:15 | 2nd (2nd leg): 09/08/2022 23:15 | Winner: Atlético Goianiense | ||||
| 1st(1st leg) | Deportivo Táchira | - | Independiente del Valle | 0:1 (0:1) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Deportivo Táchira | 4:1 (2:1) | ||
| 1st(1st leg): 03/08/2022 01:30 | 2nd (2nd leg): 10/08/2022 01:30 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | São Paulo FC | - | Ceará - CE | 1:0 (0:0) | ||
| 2nd (2nd leg) | Ceará - CE | - | São Paulo FC | 3:4 (1:0, 2:1) pso | ||
| 1st(1st leg): 03/08/2022 23:15 | 2nd (2nd leg): 10/08/2022 23:15 | Winner: São Paulo FC | ||||
| 1st(1st leg) | FBC Melgar | - | Internacional | 0:0 (0:0) | ||
| 2nd (2nd leg) | Internacional | - | FBC Melgar | 1:3 (0:0, 0:0) pso | ||
| 1st(1st leg): 04/08/2022 23:15 | 2nd (2nd leg): 11/08/2022 23:15 | Winner: FBC Melgar | ||||
