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| 1st(1st leg) | Santos de Guápiles | - | Barrio México | 3:0 | ||
| 2nd (2nd leg) | Barrio México | - | Santos de Guápiles | 0:3 | ||
| 1st(1st leg): 13/11/2010 | 2nd (2nd leg): 20/11/2010 | Winner: Santos de Guápiles | ||||
| 1st(1st leg) | Brujas de Escazú | - | CS Cartaginés | 2:3 (2:1) | ||
| 2nd (2nd leg) | CS Cartaginés | - | Brujas de Escazú | 1:1 (1:1) | ||
| 1st(1st leg): 13/11/2010 21:00 | 2nd (2nd leg): 21/11/2010 17:00 | Winner: CS Cartaginés | ||||
| 1st(1st leg) | AD San Carlos | - | CS Herediano | 2:0 (1:0) | ||
| 2nd (2nd leg) | CS Herediano | - | AD San Carlos | 4:0 (3:0) | ||
| 1st(1st leg): 14/11/2010 01:00 | 2nd (2nd leg): 21/11/2010 02:00 | Winner: CS Herediano | ||||
| 1st(1st leg) | Municipal Pérez Zeledón | - | LD Alajuelense | 2:2 (0:2) | ||
| 2nd (2nd leg) | LD Alajuelense | - | Municipal Pérez Zeledón | 4:1 (1:1) | ||
| 1st(1st leg): 14/11/2010 03:00 | 2nd (2nd leg): 21/11/2010 17:00 | Winner: LD Alajuelense | ||||
