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| 1st(1st leg) | Deportivo Saprissa | - | CS Herediano | 3:0 (2:0) | ||
| 2nd (2nd leg) | CS Herediano | - | Deportivo Saprissa | 1:0 (1:0) | ||
| 1st(1st leg): 02/12/2021 02:00 | 2nd (2nd leg): 06/12/2021 01:30 | Winner: Deportivo Saprissa | ||||
| 1st(1st leg) | Santos de Guápiles | - | LD Alajuelense | 3:2 (2:1) | ||
| 2nd (2nd leg) | LD Alajuelense | - | Santos de Guápiles | 1:0 (1:0) | ||
| 1st(1st leg): 03/12/2021 01:00 | 2nd (2nd leg): 05/12/2021 22:00 | Winner: LD Alajuelense | ||||
