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| 1st(1st leg) | Ermis Aradippou | - | Enosis Neon Paralimni | 1:1 | ||
| 2nd (2nd leg) | Enosis Neon Paralimni | - | Ermis Aradippou | 5:0 (2:0) | ||
| 1st(1st leg): 12/01/2022 12:30 | 2nd (2nd leg): 19/01/2022 13:30 | Winner: Enosis Neon Paralimni | ||||
| 1st(1st leg) | Onisilos Sotiras | - | Karmiotissa Polemidion | 4:3 | ||
| 2nd (2nd leg) | Karmiotissa Polemidion | - | Onisilos Sotiras | 0:1 (0:1) | ||
| 1st(1st leg): 12/01/2022 12:30 | 2nd (2nd leg): 19/01/2022 11:30 | Winner: Onisilos Sotiras | ||||
| 1st(1st leg) | AEK Larnaca | - | PAEEK | 1:1 (0:0) | ||
| 2nd (2nd leg) | PAEEK | - | AEK Larnaca | 2:2 | ||
| 1st(1st leg): 18/01/2022 17:00 | 2nd (2nd leg): 02/03/2022 17:00 | Winner: AEK Larnaca | ||||
| 1st(1st leg) | Paphos FC | - | Anorthosis Famagusta | 1:3 (1:0) | ||
| 2nd (2nd leg) | Anorthosis Famagusta | - | Paphos FC | 0:0 | ||
| 1st(1st leg): 19/01/2022 14:30 | 2nd (2nd leg): 03/02/2022 16:00 | Winner: Anorthosis Famagusta | ||||
| 1st(1st leg) | APOEL Nikosia | - | Olympiakos Nikosia | 2:1 (1:1) | ||
| 2nd (2nd leg) | Olympiakos Nikosia | - | APOEL Nikosia | 0:4 (0:1) | ||
| 1st(1st leg): 19/01/2022 17:00 | 2nd (2nd leg): 02/02/2022 16:00 | Winner: APOEL Nikosia | ||||
| 1st(1st leg) | P.O. Xylotymbou | - | Omonia Nikosia | 0:5 (0:1) | ||
| 2nd (2nd leg) | Omonia Nikosia | - | P.O. Xylotymbou | 2:1 (1:1) | ||
| 1st(1st leg): 20/01/2022 15:00 | 2nd (2nd leg): 01/02/2022 15:00 | Winner: Omonia Nikosia | ||||
| 1st(1st leg) | Ethnikos Achna | - | Doxa Katokopias | 3:1 (1:0) | ||
| 2nd (2nd leg) | Doxa Katokopias | - | Ethnikos Achna | 0:0 | ||
| 1st(1st leg): 26/01/2022 14:00 | 2nd (2nd leg): 03/02/2022 15:00 | Winner: Ethnikos Achna | ||||
| 1st(1st leg) | Apollon Limassol | - | AEL Limassol | 1:0 (0:0) | ||
| 2nd (2nd leg) | AEL Limassol | - | Apollon Limassol | 2:0 aet | ||
| 1st(1st leg): 26/01/2022 16:00 | 2nd (2nd leg): 02/03/2022 17:00 | Winner: AEL Limassol | ||||
