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| 1st(1st leg) | Dynamo České Budějovice | - | FK Mladá Boleslav | 2:3 (1:3) | ||
| 2nd (2nd leg) | FK Mladá Boleslav | - | Dynamo České Budějovice | 1:0 (0:0) | ||
| 1st(1st leg): 24/04/2022 15:00 | 2nd (2nd leg): 30/04/2022 15:00 | Winner: FK Mladá Boleslav | ||||
| 1st(1st leg) | Sigma Olomouc | - | Slovan Liberec | 1:0 (1:0) | ||
| 2nd (2nd leg) | Slovan Liberec | - | Sigma Olomouc | 0:2 (0:1) | ||
| 1st(1st leg): 24/04/2022 15:00 | 2nd (2nd leg): 30/04/2022 15:00 | Winner: Sigma Olomouc | ||||
