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| 19/11/2021 | 15:30 | FK Ústí nad Labem | - | SFC Opava | 0:2 (0:2) | |
| 20/11/2021 | 09:15 | MFK Vyškov | - | FK Fotbal Třinec | 1:4 (1:2) | |
| 12:30 | 1. FK Příbram | - | Vysočina Jihlava | 1:1 (1:1) | ||
| 21/11/2021 | 09:15 | Viktoria Žižkov | - | FK MAS Táborsko | 0:0 (0:0) | |
| 09:30 | AC Sparta Praha B | - | SK Líšeň | 2:1 (1:0) | ||
| 12:30 | FK Varnsdorf | - | 1. SK Prostějov | 3:1 (0:1) | ||
| 12:30 | FC Sellier & Bellot Vlašim | - | FK Dukla Praha | 2:0 (1:0) | ||
| 13:00 | Zbrojovka Brno | - | MFK Chrudim | 3:2 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 15 | 11 | 2 | 2 | 30:15 | 15 | 35 |
| 2 |
|
AC Sparta Praha B | 15 | 9 | 1 | 5 | 30:18 | 12 | 28 |
| 3 |
|
SK Líšeň | 15 | 8 | 4 | 3 | 25:15 | 10 | 28 |
| 4 |
|
FC Sellier & Bellot Vlašim | 15 | 8 | 2 | 5 | 31:19 | 12 | 26 |
| 5 |
|
SFC Opava | 15 | 7 | 4 | 4 | 24:15 | 9 | 25 |
| 6 |
|
FK Dukla Praha | 15 | 7 | 2 | 6 | 21:21 | 0 | 23 |
| 7 |
|
1. SK Prostějov | 15 | 7 | 2 | 6 | 16:20 | -4 | 23 |
| 8 |
|
FK Varnsdorf | 15 | 6 | 4 | 5 | 26:23 | 3 | 22 |
| 9 |
|
FK MAS Táborsko | 15 | 6 | 4 | 5 | 16:16 | 0 | 22 |
| 10 |
|
Vysočina Jihlava | 15 | 5 | 5 | 5 | 13:16 | -3 | 20 |
| 11 |
|
FK Ústí nad Labem | 15 | 4 | 6 | 5 | 15:20 | -5 | 18 |
| 12 |
|
MFK Vyškov | 15 | 5 | 2 | 8 | 26:25 | 1 | 17 |
| 13 |
|
1. FK Příbram | 15 | 3 | 5 | 7 | 18:27 | -9 | 14 |
| 14 |
|
FK Fotbal Třinec | 15 | 4 | 1 | 10 | 14:30 | -16 | 13 |
| 15 |
|
Viktoria Žižkov | 15 | 2 | 4 | 9 | 13:25 | -12 | 10 |
| 16 |
|
MFK Chrudim | 15 | 2 | 4 | 9 | 13:26 | -13 | 10 |
| Promotion | |
| Playoffs | |
| Relegation |
