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| 14/05/2022 | 16:30 | Zbrojovka Brno | - | FK MAS Táborsko | 1:1 (0:1) | |
| 16:30 | 1. FK Příbram | - | 1. SK Prostějov | 2:4 (0:2) | ||
| 16:30 | FK Ústí nad Labem | - | FK Fotbal Třinec | 3:2 (2:1) | ||
| 16:30 | FK Varnsdorf | - | Vysočina Jihlava | 0:0 (0:0) | ||
| 16:30 | Viktoria Žižkov | - | SK Líšeň | 3:1 (0:0) | ||
| 16:30 | MFK Vyškov | - | FK Dukla Praha | 1:1 (0:0) | ||
| 16:30 | AC Sparta Praha B | - | MFK Chrudim | 2:2 (0:1) | ||
| 16:30 | FC Sellier & Bellot Vlašim | - | SFC Opava | 3:1 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 30 | 22 | 3 | 5 | 61:29 | 32 | 69 |
| 2 |
|
FC Sellier & Bellot Vlašim | 30 | 16 | 5 | 9 | 61:39 | 22 | 53 |
| 3 |
|
SFC Opava | 30 | 14 | 9 | 7 | 47:33 | 14 | 51 |
| 4 |
|
SK Líšeň | 30 | 14 | 8 | 8 | 45:33 | 12 | 50 |
| 5 |
|
AC Sparta Praha B | 30 | 13 | 7 | 10 | 50:37 | 13 | 46 |
| 6 |
|
FK Varnsdorf | 30 | 13 | 6 | 11 | 47:35 | 12 | 45 |
| 7 |
|
Vysočina Jihlava | 30 | 11 | 9 | 10 | 29:34 | -5 | 42 |
| 8 |
|
FK MAS Táborsko | 30 | 10 | 10 | 10 | 33:34 | -1 | 40 |
| 9 |
|
FK Dukla Praha | 30 | 10 | 9 | 11 | 40:41 | -1 | 39 |
| 10 |
|
MFK Chrudim | 30 | 9 | 11 | 10 | 32:36 | -4 | 38 |
| 11 |
|
1. SK Prostějov | 30 | 11 | 4 | 15 | 32:50 | -18 | 37 |
| 12 |
|
MFK Vyškov | 30 | 9 | 8 | 13 | 43:44 | -1 | 35 |
| 13 |
|
1. FK Příbram | 30 | 9 | 8 | 13 | 38:51 | -13 | 35 |
| 14 |
|
FK Fotbal Třinec | 30 | 9 | 6 | 15 | 38:54 | -16 | 33 |
| 15 |
|
FK Ústí nad Labem | 30 | 6 | 10 | 14 | 26:49 | -23 | 28 |
| 16 |
|
Viktoria Žižkov | 30 | 3 | 9 | 18 | 29:52 | -23 | 18 |
| Promotion | |
| Playoffs | |
| Relegation |
