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| 1st(1st leg) | SFC Opava | - | Bohemians Praha 1905 | 0:1 (0:1) | ||
| 2nd (2nd leg) | Bohemians Praha 1905 | - | SFC Opava | 2:0 (1:0) | ||
| 1st(1st leg): 19/05/2022 16:00 | 2nd (2nd leg): 22/05/2022 15:00 | Winner: Bohemians Praha 1905 | ||||
| 1st(1st leg) | FK Teplice | - | FC Sellier & Bellot Vlašim | 3:0 (1:0) | ||
| 2nd (2nd leg) | FC Sellier & Bellot Vlašim | - | FK Teplice | 2:2 (2:1) | ||
| 1st(1st leg): 19/05/2022 16:00 | 2nd (2nd leg): 22/05/2022 15:00 | Winner: FK Teplice | ||||
