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| 1st(1st leg) | Fremad Amager | - | SønderjyskE | 1:2 (0:1) | ||
| 2nd (2nd leg) | SønderjyskE | - | Fremad Amager | 4:1 (2:0) | ||
| 1st(1st leg): 10/02/2021 17:00 | 2nd (2nd leg): 11/03/2021 15:30 | Winner: SønderjyskE | ||||
| 1st(1st leg) | Aarhus GF | - | B.93 København | 3:1 (1:0) | ||
| 2nd (2nd leg) | B.93 København | - | Aarhus GF | 2:1 (1:0) | ||
| 1st(1st leg): 10/02/2021 19:15 | 2nd (2nd leg): 11/03/2021 17:45 | Winner: Aarhus GF | ||||
| 1st(1st leg) | Odense BK | - | FC Midtjylland | 1:2 (1:1) | ||
| 2nd (2nd leg) | FC Midtjylland | - | Odense BK | 3:0 (1:0) | ||
| 1st(1st leg): 11/02/2021 17:00 | 2nd (2nd leg): 10/03/2021 15:30 | Winner: FC Midtjylland | ||||
| 1st(1st leg) | Vejle BK | - | Randers FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Randers FC | - | Vejle BK | 3:1 (3:1) | ||
| 1st(1st leg): 11/02/2021 19:15 | 2nd (2nd leg): 10/03/2021 17:00 | Winner: Randers FC | ||||
