1st(1st leg) Werder Bremen - Aarhus GF 2:0 (1:0)
2nd (2nd leg) Aarhus GF - Werder Bremen 2:3 (0:1)
1st(1st leg): 25/10/1961 2nd (2nd leg): 01/11/1961 Winner: Werder Bremen
1st(1st leg) Dunfermline Athletic - Vardar Skopje 5:0 (3:0)
2nd (2nd leg) Vardar Skopje - Dunfermline Athletic 2:0 (1:0)
1st(1st leg): 25/10/1961 2nd (2nd leg): 08/11/1961 Winner: Dunfermline Athletic
1st(1st leg) Leicester City - Atlético Madrid 1:1 (0:0)
2nd (2nd leg) Atlético Madrid - Leicester City 2:0 (0:0)
1st(1st leg): 25/10/1961 2nd (2nd leg): 15/11/1961 Winner: Atlético Madrid
1st(1st leg) ACF Fiorentina - Rapid Wien 3:1 (2:0)
2nd (2nd leg) Rapid Wien - ACF Fiorentina 2:6 (0:2)
1st(1st leg): 25/10/1961 2nd (2nd leg): 22/11/1961 Winner: ACF Fiorentina
1st(1st leg) AFC Ajax - Újpesti Dózsa SC 2:1 (2:0)
2nd (2nd leg) Újpesti Dózsa SC - AFC Ajax 3:1 (1:0)
1st(1st leg): 02/11/1961 2nd (2nd leg): 29/11/1961 Winner: Újpesti Dózsa SC
1st(1st leg) Olympiakos Piraeus - DŠO Dynamo Žilina 2:3 (1:2)
2nd (2nd leg) DŠO Dynamo Žilina - Olympiakos Piraeus 1:0 (1:0)
1st(1st leg): 22/11/1961 2nd (2nd leg): 30/11/1961 Winner: DŠO Dynamo Žilina
1st(1st leg) Leixões SC - FC Progresul Bucureşti 1:1 (0:1)
2nd (2nd leg) FC Progresul Bucureşti - Leixões SC 0:1 (0:0)
1st(1st leg): 23/11/1961 2nd (2nd leg): 30/11/1961 Winner: Leixões SC
1st(1st leg) SC Motor Jena - Alliance Dudelange 7:0 (3:0)
2nd (2nd leg) Alliance Dudelange - SC Motor Jena 2:2 (1:0)
1st(1st leg): 17/12/1961 2nd (2nd leg): 19/12/1961 Winner: SC Motor Jena