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| 1st(1st leg) | K Waterschei SV Thor Genk | - | Fortuna Düsseldorf | 0:0 (0:0) | ||
| 2nd (2nd leg) | Fortuna Düsseldorf | - | K Waterschei SV Thor Genk | 1:0 (1:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Fortuna Düsseldorf | ||||
| 1st(1st leg) | FC Carl Zeiss Jena | - | Valencia CF | 3:1 (3:0) | ||
| 2nd (2nd leg) | Valencia CF | - | FC Carl Zeiss Jena | 1:0 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: FC Carl Zeiss Jena | ||||
| 1st(1st leg) | Waterford AFC | - | Dinamo Tbilisi | 0:1 (0:0) | ||
| 2nd (2nd leg) | Dinamo Tbilisi | - | Waterford AFC | 4:0 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Dinamo Tbilisi | ||||
| 1st(1st leg) | West Ham United | - | CS Politechnica Timisoara | 4:0 (3:0) | ||
| 2nd (2nd leg) | CS Politechnica Timisoara | - | West Ham United | 1:0 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: West Ham United | ||||
| 1st(1st leg) | Hvidovre IF | - | Feyenoord | 1:2 (1:1) | ||
| 2nd (2nd leg) | Feyenoord | - | Hvidovre IF | 1:0 (1:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Feyenoord | ||||
| 1st(1st leg) | Malmö FF | - | SL Benfica | 1:0 (0:0) | ||
| 2nd (2nd leg) | SL Benfica | - | Malmö FF | 2:0 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: SL Benfica | ||||
| 1st(1st leg) | TJ Sparta ČKD Praha | - | Slavia Sofia | 2:0 (2:0) | ||
| 2nd (2nd leg) | Slavia Sofia | - | TJ Sparta ČKD Praha | 3:0 (3:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Slavia Sofia | ||||
| 1st(1st leg) | SK Haugar | - | Newport County | 0:0 (0:0) | ||
| 2nd (2nd leg) | Newport County | - | SK Haugar | 6:0 (2:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 04/11/1980 | Winner: Newport County | ||||
