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| 1st(1st leg) | Gloria | - | Audaz Octubrino | 2:1 | ||
| 2nd (2nd leg) | Audaz Octubrino | - | Gloria | 7:6 pso | ||
| 1st(1st leg): 23/11/2018 21:00 | 2nd (2nd leg): 01/12/2018 19:30 | Winner: Audaz Octubrino | ||||
| 1st(1st leg) | Brasilia | - | Toreros FC | 0:0 | ||
| 2nd (2nd leg) | Toreros FC | - | Brasilia | 1:0 | ||
| 1st(1st leg): 25/11/2018 18:00 | 2nd (2nd leg): 03/12/2018 01:00 | Winner: Toreros FC | ||||
| 1st(1st leg) | Deportivo Quito | - | Mineros SC | 2:0 | ||
| 2nd (2nd leg) | Mineros SC | - | Deportivo Quito | 1:1 | ||
| 1st(1st leg): 25/11/2018 18:00 | 2nd (2nd leg): 02/12/2018 20:00 | Winner: Deportivo Quito | ||||
| 1st(1st leg) | Dunamis TCE | - | Anaconda FC | 3:1 | ||
| 2nd (2nd leg) | Anaconda FC | - | Dunamis TCE | 1:2 | ||
| 1st(1st leg): 25/11/2018 19:00 | 2nd (2nd leg): 02/12/2018 18:00 | Winner: Dunamis TCE | ||||
| 1st(1st leg) | Atlético Portoviejo | - | FC Insutec | 4:3 | ||
| 2nd (2nd leg) | FC Insutec | - | Atlético Portoviejo | 0:2 | ||
| 1st(1st leg): 28/11/2018 21:00 | 2nd (2nd leg): 05/12/2018 22:00 | Winner: Atlético Portoviejo | ||||
| 1st(1st leg) | Independiente Juniors | - | Alianza de Guano | 1:3 | ||
| 2nd (2nd leg) | Alianza de Guano | - | Independiente Juniors | 2:0 | ||
| 1st(1st leg): 28/11/2018 21:30 | 2nd (2nd leg): 05/12/2018 21:00 | Winner: Alianza de Guano | ||||
