1st(1st leg) LDU Quito - Barcelona 2:0 (1:0)
2nd (2nd leg) Barcelona - LDU Quito 0:1 (0:0)
1st(1st leg): 07/08/2021 16:30 2nd (2nd leg): 14/08/2021 19:00 Winner: LDU Quito
1st(1st leg) Espuce FC - Deportivo Cuenca 0:1 (0:0)
2nd (2nd leg) Deportivo Cuenca - Espuce FC 1:0 (0:0)
1st(1st leg): 07/08/2021 19:00 2nd (2nd leg): 15/08/2021 16:30 Winner: Deportivo Cuenca
1st(1st leg) UPS Carneras - Dragonas IDV 0:1 (0:0)
2nd (2nd leg) Dragonas IDV - UPS Carneras 3:0 (1:0)
1st(1st leg): 08/08/2021 16:30 2nd (2nd leg): 15/08/2021 16:30 Winner: Dragonas IDV
1st(1st leg) Macará - Ñañas 2:4 (1:2)
2nd (2nd leg) Ñañas - Macará 5:1 (0:1)
1st(1st leg): 08/08/2021 19:00 2nd (2nd leg): 14/08/2021 16:30 Winner: Ñañas