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| 1st(1st leg) | Quito FC | - | Deportivo Ibarra | 1:3 (1:0) | ||
| 2nd (2nd leg) | Deportivo Ibarra | - | Quito FC | 2:0 (0:0) | ||
| 1st(1st leg): 21/08/2022 17:00 | 2nd (2nd leg): 28/08/2022 16:00 | Winner: Deportivo Ibarra | ||||
| 1st(1st leg) | Espuce FC | - | Barcelona | 0:1 (0:0) | ||
| 2nd (2nd leg) | Barcelona | - | Espuce FC | 4:0 (2:0) | ||
| 1st(1st leg): 21/08/2022 19:00 | 2nd (2nd leg): 27/08/2022 01:00 | Winner: Barcelona | ||||
| 1st(1st leg) | Universidad Católica | - | Dragonas IDV | 1:4 (1:2) | ||
| 2nd (2nd leg) | Dragonas IDV | - | Universidad Católica | 2:3 (1:0) | ||
| 1st(1st leg): 21/08/2022 20:00 | 2nd (2nd leg): 29/08/2022 01:15 | Winner: Dragonas IDV | ||||
| 1st(1st leg) | LDU Quito | - | Ñañas | 0:3 (0:2) | ||
| 2nd (2nd leg) | Ñañas | - | LDU Quito | 1:0 (0:0) | ||
| 1st(1st leg): 21/08/2022 23:00 | 2nd (2nd leg): 27/08/2022 21:00 | Winner: Ñañas | ||||
