 |
 |
|
|
| 1st(1st leg) | Cumbayá | - | Emelec | 1:5 (0:1) | ||
| 2nd (2nd leg) | Emelec | - | Cumbayá | 7:1 (4:0) | ||
| 1st(1st leg): 02/09/2022 18:00 | 2nd (2nd leg): 10/09/2022 20:30 | Winner: Emelec | ||||
| 1st(1st leg) | Mushuc Runa | - | Independiente del Valle | 2:3 (0:1) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Mushuc Runa | 6:2 (1:1) | ||
| 1st(1st leg): 03/09/2022 15:30 | 2nd (2nd leg): 10/09/2022 15:30 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Barcelona | - | Delfin SC | 3:2 (1:1) | ||
| 2nd (2nd leg) | Delfin SC | - | Barcelona | 0:3 (0:1) | ||
| 1st(1st leg): 03/09/2022 17:00 | 2nd (2nd leg): 09/09/2022 15:00 | Winner: Barcelona | ||||
| 1st(1st leg) | LDU Quito | - | Búhos ULVR | 1:0 (0:0) | ||
| 2nd (2nd leg) | Búhos ULVR | - | LDU Quito | 9:8 (2:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 03/09/2022 17:15 | 2nd (2nd leg): 10/09/2022 18:00 | Winner: Búhos ULVR | ||||
