1st(1st leg) Tranmere Rovers - Port Vale FC 2:0
2nd (2nd leg) Port Vale FC - Tranmere Rovers 1:2
1st(1st leg): 05/10/1981 2nd (2nd leg): 28/10/1981 Winner: Tranmere Rovers
1st(1st leg) Aldershot FC - Wigan Athletic 2:2
2nd (2nd leg) Wigan Athletic - Aldershot FC 1:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Wigan Athletic
1st(1st leg) Barnsley FC - Swansea City 2:0
2nd (2nd leg) Swansea City - Barnsley FC 3:2 aet
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Barnsley FC
1st(1st leg) Birmingham City - Nottingham Forest 2:3
2nd (2nd leg) Nottingham Forest - Birmingham City 2:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 28/10/1981 Winner: Nottingham Forest
1st(1st leg) Bristol Rovers - Northampton Town 1:2
2nd (2nd leg) Northampton Town - Bristol Rovers 3:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Northampton Town
1st(1st leg) Carlisle United - Bristol City 0:0
2nd (2nd leg) Bristol City - Carlisle United 2:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Bristol City
1st(1st leg) Colchester United - Cambridge United 3:1
2nd (2nd leg) Cambridge United - Colchester United 3:2 aet
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Colchester United
1st(1st leg) Doncaster Rovers - Crystal Palace 1:0
2nd (2nd leg) Crystal Palace - Doncaster Rovers 2:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Crystal Palace
1st(1st leg) Everton FC - Coventry City 1:1
2nd (2nd leg) Coventry City - Everton FC 0:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Everton FC
1st(1st leg) Grimsby Town - Watford FC 1:0
2nd (2nd leg) Watford FC - Grimsby Town 3:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Watford FC
1st(1st leg) Huddersfield Town - Brighton & Hove Albion 1:0
2nd (2nd leg) Brighton & Hove Albion - Huddersfield Town 2:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Brighton & Hove Albion
1st(1st leg) Luton Town - Wrexham AFC 0:2
2nd (2nd leg) Wrexham AFC - Luton Town 0:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Wrexham AFC
1st(1st leg) Middlesbrough FC - Plymouth Argyle 2:1
2nd (2nd leg) Plymouth Argyle - Middlesbrough FC 0:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Middlesbrough FC
1st(1st leg) Millwall FC - Oxford United 3:3
2nd (2nd leg) Oxford United - Millwall FC 1:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 28/10/1981 Winner: Oxford United
1st(1st leg) Oldham Athletic - Newport County 1:0
2nd (2nd leg) Newport County - Oldham Athletic 0:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Oldham Athletic
1st(1st leg) Preston North End - Leicester City 1:0
2nd (2nd leg) Leicester City - Preston North End 4:0
1st(1st leg): 06/10/1981 2nd (2nd leg): 28/10/1981 Winner: Leicester City
1st(1st leg) Queens Park Rangers - Portsmouth FC 5:0
2nd (2nd leg) Portsmouth FC - Queens Park Rangers 2:2
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Queens Park Rangers
1st(1st leg) Sheffield United - Arsenal FC 1:0
2nd (2nd leg) Arsenal FC - Sheffield United 2:0 aet
1st(1st leg): 06/10/1981 2nd (2nd leg): 27/10/1981 Winner: Arsenal FC
1st(1st leg) Shrewsbury Town - West Bromwich Albion 3:3
2nd (2nd leg) West Bromwich Albion - Shrewsbury Town 2:1
1st(1st leg): 06/10/1981 2nd (2nd leg): 28/10/1981 Winner: West Bromwich Albion
1st(1st leg) Southampton FC - Chelsea FC 1:1
2nd (2nd leg) Chelsea FC - Southampton FC 2:1 aet
1st(1st leg): 06/10/1981 2nd (2nd leg): 28/10/1981 Winner: Chelsea FC
1st(1st leg) Aston Villa - Wolverhampton Wanderers 3:2
2nd (2nd leg) Wolverhampton Wanderers - Aston Villa 1:2
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: Aston Villa
1st(1st leg) Blackburn Rovers - Sheffield Wednesday 1:1
2nd (2nd leg) Sheffield Wednesday - Blackburn Rovers 1:2
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: Blackburn Rovers
1st(1st leg) Bradford City - Mansfield Town 3:4
2nd (2nd leg) Mansfield Town - Bradford City 0:2
1st(1st leg): 07/10/1981 2nd (2nd leg): 26/10/1981 Winner: Bradford City
1st(1st leg) Derby County - West Ham United 2:3
2nd (2nd leg) West Ham United - Derby County 2:0
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: West Ham United
1st(1st leg) Leeds United - Ipswich Town 0:1
2nd (2nd leg) Ipswich Town - Leeds United 3:0
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: Ipswich Town
1st(1st leg) Lincoln City - Notts County 1:1
2nd (2nd leg) Notts County - Lincoln City 2:3
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: Lincoln City
1st(1st leg) Liverpool FC - Exeter City 5:0
2nd (2nd leg) Exeter City - Liverpool FC 0:6
1st(1st leg): 07/10/1981 2nd (2nd leg): 28/10/1981 Winner: Liverpool FC
1st(1st leg) Manchester City - Stoke City 2:0
2nd (2nd leg) Stoke City - Manchester City 8:9 pso
1st(1st leg): 07/10/1981 2nd (2nd leg): 28/10/1981 Winner: Manchester City
1st(1st leg) Newcastle United - Fulham FC 1:2
2nd (2nd leg) Fulham FC - Newcastle United 2:0
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: Fulham FC
1st(1st leg) Norwich City - Charlton Athletic 1:0
2nd (2nd leg) Charlton Athletic - Norwich City 0:1
1st(1st leg): 07/10/1981 2nd (2nd leg): 28/10/1981 Winner: Norwich City
1st(1st leg) Sunderland AFC - Rotherham United 2:0
2nd (2nd leg) Rotherham United - Sunderland AFC 3:3
1st(1st leg): 07/10/1981 2nd (2nd leg): 27/10/1981 Winner: Sunderland AFC
1st(1st leg) Tottenham Hotspur - Manchester United 1:0
2nd (2nd leg) Manchester United - Tottenham Hotspur 0:1
1st(1st leg): 07/10/1981 2nd (2nd leg): 28/10/1981 Winner: Tottenham Hotspur