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| 1st(1st leg) | Martos CD | - | Real Valladolid | 1:1 | ||
| 2nd (2nd leg) | Real Valladolid | - | Martos CD | 6:1 | ||
| 1st(1st leg): 24/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: Real Valladolid | ||||
| 1st(1st leg) | Rayo Vallecano | - | Real Oviedo | 2:0 | ||
| 2nd (2nd leg) | Real Oviedo | - | Rayo Vallecano | 0:0 | ||
| 1st(1st leg): 24/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: Rayo Vallecano | ||||
| 1st(1st leg) | Athletic Bilbao | - | Barcelona Atlètic | 2:0 | ||
| 2nd (2nd leg) | Barcelona Atlètic | - | Athletic Bilbao | 0:1 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 09/12/1981 | Winner: Athletic Bilbao | ||||
| 1st(1st leg) | Atlético Madrileño | - | Castilla CF | 1:0 | ||
| 2nd (2nd leg) | Castilla CF | - | Atlético Madrileño | 1:2 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 10/12/1981 | Winner: Atlético Madrileño | ||||
| 1st(1st leg) | FC Barcelona C | - | Atlético Madrid | 1:1 | ||
| 2nd (2nd leg) | Atlético Madrid | - | FC Barcelona C | 3:2 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | RC Celta | - | CD Alavés | 1:0 | ||
| 2nd (2nd leg) | CD Alavés | - | RC Celta | 5:4 pso | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: CD Alavés | ||||
| 1st(1st leg) | Deportivo La Coruña | - | CD Tenerife | 2:1 | ||
| 2nd (2nd leg) | CD Tenerife | - | Deportivo La Coruña | 3:4 pso | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 09/12/1981 | Winner: Deportivo La Coruña | ||||
| 1st(1st leg) | Elche CF | - | Gran Peña FC | 2:0 | ||
| 2nd (2nd leg) | Gran Peña FC | - | Elche CF | 1:2 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 09/12/1981 | Winner: Elche CF | ||||
| 1st(1st leg) | UD Las Palmas | - | Levante UD | 6:1 | ||
| 2nd (2nd leg) | Levante UD | - | UD Las Palmas | 0:0 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: UD Las Palmas | ||||
| 1st(1st leg) | CD Málaga | - | AD Ceuta | 3:2 | ||
| 2nd (2nd leg) | AD Ceuta | - | CD Málaga | dnp | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: CD Málaga | ||||
| 1st(1st leg) | CD Binéfar | - | RCD Mallorca | 3:1 | ||
| 2nd (2nd leg) | RCD Mallorca | - | CD Binéfar | 3:2 pso | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 09/12/1981 | Winner: RCD Mallorca | ||||
| 1st(1st leg) | Real Murcia | - | UD Salamanca | 1:0 | ||
| 2nd (2nd leg) | UD Salamanca | - | Real Murcia | 2:0 aet | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: UD Salamanca | ||||
| 1st(1st leg) | CA Osasuna | - | Real Sociedad | 1:1 | ||
| 2nd (2nd leg) | Real Sociedad | - | CA Osasuna | 3:1 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 09/12/1981 | Winner: Real Sociedad | ||||
| 1st(1st leg) | Sevilla Atlético | - | Hércules CF | 0:2 | ||
| 2nd (2nd leg) | Hércules CF | - | Sevilla Atlético | 3:3 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 08/12/1981 | Winner: Hércules CF | ||||
| 1st(1st leg) | Sporting Gijón | - | CD Castellón | 3:1 | ||
| 2nd (2nd leg) | CD Castellón | - | Sporting Gijón | 2:1 | ||
| 1st(1st leg): 25/11/1981 | 2nd (2nd leg): 09/12/1981 | Winner: Sporting Gijón | ||||
| 1st(1st leg) | Espanyol Barcelona | - | Real Zaragoza | 2:0 | ||
| 2nd (2nd leg) | Real Zaragoza | - | Espanyol Barcelona | 1:2 | ||
| 1st(1st leg): 09/12/1981 | 2nd (2nd leg): 23/12/1981 | Winner: Espanyol Barcelona | ||||
