1st(1st leg) Real Murcia - Real Madrid 0:0 (0:0)
2nd (2nd leg) Real Madrid - Real Murcia 5:1 (2:0)
1st(1st leg): 26/10/2010 19:00 2nd (2nd leg): 10/11/2010 19:00 Winner: Real Madrid
1st(1st leg) AD Ceuta - FC Barcelona 0:2 (0:2)
2nd (2nd leg) FC Barcelona - AD Ceuta 5:1 (2:1)
1st(1st leg): 26/10/2010 21:00 2nd (2nd leg): 10/11/2010 21:00 Winner: FC Barcelona
1st(1st leg) Real Unión - Sevilla FC 0:4 (0:1)
2nd (2nd leg) Sevilla FC - Real Unión 6:1 (3:1)
1st(1st leg): 27/10/2010 19:00 2nd (2nd leg): 10/11/2010 20:00 Winner: Sevilla FC
1st(1st leg) UD Logroñés - Valencia CF 0:3 (0:0)
2nd (2nd leg) Valencia CF - UD Logroñés 4:1 (3:1)
1st(1st leg): 27/10/2010 19:00 2nd (2nd leg): 11/11/2010 20:00 Winner: Valencia CF
1st(1st leg) Córdoba CF - Racing Santander 2:0 (1:0)
2nd (2nd leg) Racing Santander - Córdoba CF 3:1 (1:0, 2:0) aet
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 09/11/2010 19:00 Winner: Córdoba CF
1st(1st leg) Xerez CD - Levante UD 2:3 (1:0)
2nd (2nd leg) Levante UD - Xerez CD 1:2 (1:1)
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 10/11/2010 20:00 Winner: Levante UD
1st(1st leg) Real Valladolid - Espanyol Barcelona 0:2 (0:1)
2nd (2nd leg) Espanyol Barcelona - Real Valladolid 1:1 (0:0)
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 09/11/2010 21:00 Winner: Espanyol Barcelona
1st(1st leg) RCD Mallorca - Sporting Gijón 3:1 (2:0)
2nd (2nd leg) Sporting Gijón - RCD Mallorca 2:2 (1:2)
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 11/11/2010 20:00 Winner: RCD Mallorca
1st(1st leg) Polideportivo Ejido - Villarreal CF 1:1 (0:1)
2nd (2nd leg) Villarreal CF - Polideportivo Ejido 2:0 (1:0)
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 10/11/2010 20:00 Winner: Villarreal CF
1st(1st leg) Hércules CF - Málaga CF 0:0 (0:0)
2nd (2nd leg) Málaga CF - Hércules CF 3:2 (2:1)
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 11/11/2010 21:00 Winner: Málaga CF
1st(1st leg) Club Portugalete - Getafe CF 1:1 (0:1)
2nd (2nd leg) Getafe CF - Club Portugalete 0:0 (0:0)
1st(1st leg): 27/10/2010 20:00 2nd (2nd leg): 11/11/2010 19:00 Winner: Getafe CF
1st(1st leg) Universidad Las Palmas - Atlético Madrid 0:5 (0:2)
2nd (2nd leg) Atlético Madrid - Universidad Las Palmas 1:1 (0:1)
1st(1st leg): 27/10/2010 21:00 2nd (2nd leg): 10/11/2010 20:00 Winner: Atlético Madrid
1st(1st leg) Real Betis - Real Zaragoza 0:1 (0:0)
2nd (2nd leg) Real Zaragoza - Real Betis 1:2 (1:2)
1st(1st leg): 27/10/2010 21:00 2nd (2nd leg): 10/11/2010 19:00 Winner: Real Betis
1st(1st leg) AD Alcorcón - Athletic Bilbao 0:1 (0:0)
2nd (2nd leg) Athletic Bilbao - AD Alcorcón 2:0 (1:0)
1st(1st leg): 28/10/2010 19:00 2nd (2nd leg): 10/11/2010 21:00 Winner: Athletic Bilbao
1st(1st leg) CA Osasuna - Deportivo La Coruña 1:1 (0:0)
2nd (2nd leg) Deportivo La Coruña - CA Osasuna 2:1 (0:0)
1st(1st leg): 28/10/2010 20:00 2nd (2nd leg): 10/11/2010 20:00 Winner: Deportivo La Coruña
1st(1st leg) Real Sociedad - UD Almería 2:3 (2:0)
2nd (2nd leg) UD Almería - Real Sociedad 2:1 (1:0)
1st(1st leg): 28/10/2010 21:00 2nd (2nd leg): 10/11/2010 20:00 Winner: UD Almería