1st(1st leg) CA Osasuna - Valencia CF 0:2 (0:0)
2nd (2nd leg) Valencia CF - CA Osasuna 2:1 (1:1)
1st(1st leg): 11/12/2012 19:00 2nd (2nd leg): 08/01/2013 20:30 Winner: Valencia CF
1st(1st leg) Córdoba CF - FC Barcelona 0:2 (0:1)
2nd (2nd leg) FC Barcelona - Córdoba CF 5:0 (3:0)
1st(1st leg): 12/12/2012 19:00 2nd (2nd leg): 10/01/2013 20:30 Winner: FC Barcelona
1st(1st leg) RCD Mallorca - Sevilla FC 0:5 (0:3)
2nd (2nd leg) Sevilla FC - RCD Mallorca 1:2 (1:0)
1st(1st leg): 12/12/2012 19:00 2nd (2nd leg): 09/01/2013 18:30 Winner: Sevilla FC
1st(1st leg) Atlético Madrid - Getafe CF 3:0 (1:0)
2nd (2nd leg) Getafe CF - Atlético Madrid 0:0 (0:0)
1st(1st leg): 12/12/2012 21:00 2nd (2nd leg): 10/01/2013 18:30 Winner: Atlético Madrid
1st(1st leg) RC Celta - Real Madrid 2:1 (0:0)
2nd (2nd leg) Real Madrid - RC Celta 4:0 (2:0)
1st(1st leg): 12/12/2012 21:00 2nd (2nd leg): 09/01/2013 20:30 Winner: Real Madrid
1st(1st leg) Levante UD - Real Zaragoza 0:1 (0:0)
2nd (2nd leg) Real Zaragoza - Levante UD 2:0 (1:0)
1st(1st leg): 13/12/2012 19:00 2nd (2nd leg): 09/01/2013 20:30 Winner: Real Zaragoza
1st(1st leg) UD Las Palmas - Real Betis 1:1 (0:0)
2nd (2nd leg) Real Betis - UD Las Palmas 1:0 (0:0)
1st(1st leg): 13/12/2012 21:00 2nd (2nd leg): 10/01/2013 20:30 Winner: Real Betis
1st(1st leg) SD Eibar - Málaga CF 1:1 (0:0)
2nd (2nd leg) Málaga CF - SD Eibar 4:1 (0:1)
1st(1st leg): 18/12/2012 19:00 2nd (2nd leg): 08/01/2013 18:30 Winner: Málaga CF