1st(1st leg) Athletic Bilbao - Villarreal CF 3:2 (0:2)
2nd (2nd leg) Villarreal CF - Athletic Bilbao 0:1 (0:1)
1st(1st leg): 06/01/2016 11:00 2nd (2nd leg): 13/01/2016 19:30 Winner: Athletic Bilbao
1st(1st leg) Valencia CF - Granada CF 4:0 (2:0)
2nd (2nd leg) Granada CF - Valencia CF 0:3 (0:1)
1st(1st leg): 06/01/2016 15:00 2nd (2nd leg): 14/01/2016 19:00 Winner: Valencia CF
1st(1st leg) CD Mirandés - Deportivo La Coruña 1:1 (1:0)
2nd (2nd leg) Deportivo La Coruña - CD Mirandés 0:3 (0:1)
1st(1st leg): 06/01/2016 15:00 2nd (2nd leg): 12/01/2016 19:30 Winner: CD Mirandés
1st(1st leg) Real Betis - Sevilla FC 0:2 (0:1)
2nd (2nd leg) Sevilla FC - Real Betis 4:0 (2:0)
1st(1st leg): 06/01/2016 17:15 2nd (2nd leg): 12/01/2016 19:30 Winner: Sevilla FC
1st(1st leg) FC Barcelona - Espanyol Barcelona 4:1 (2:1)
2nd (2nd leg) Espanyol Barcelona - FC Barcelona 0:2 (0:1)
1st(1st leg): 06/01/2016 19:30 2nd (2nd leg): 13/01/2016 20:00 Winner: FC Barcelona
1st(1st leg) Rayo Vallecano - Atlético Madrid 1:1 (1:0)
2nd (2nd leg) Atlético Madrid - Rayo Vallecano 3:0 (1:0)
1st(1st leg): 06/01/2016 21:05 2nd (2nd leg): 14/01/2016 19:30 Winner: Atlético Madrid
1st(1st leg) Cádiz CF - RC Celta 0:3 (0:1)
2nd (2nd leg) RC Celta - Cádiz CF 2:0 (1:0)
1st(1st leg): 07/01/2016 19:30 2nd (2nd leg): 13/01/2016 19:30 Winner: RC Celta
1st(1st leg) SD Eibar - UD Las Palmas 2:3 (2:1)
2nd (2nd leg) UD Las Palmas - SD Eibar 3:2 (1:0)
1st(1st leg): 07/01/2016 19:30 2nd (2nd leg): 13/01/2016 20:00 Winner: UD Las Palmas