1st(1st leg) RC Celta - Atlético Madrid 0:0 (0:0)
2nd (2nd leg) Atlético Madrid - RC Celta 2:3 (1:1)
1st(1st leg): 20/01/2016 19:30 2nd (2nd leg): 27/01/2016 19:30 Winner: RC Celta
1st(1st leg) Athletic Bilbao - FC Barcelona 1:2 (0:2)
2nd (2nd leg) FC Barcelona - Athletic Bilbao 3:1 (0:1)
1st(1st leg): 20/01/2016 20:00 2nd (2nd leg): 27/01/2016 20:30 Winner: FC Barcelona
1st(1st leg) Valencia CF - UD Las Palmas 1:1 (0:1)
2nd (2nd leg) UD Las Palmas - Valencia CF 0:1 (0:1)
1st(1st leg): 21/01/2016 19:00 2nd (2nd leg): 28/01/2016 20:00 Winner: Valencia CF
1st(1st leg) Sevilla FC - CD Mirandés 2:0 (1:0)
2nd (2nd leg) CD Mirandés - Sevilla FC 0:3 (0:1)
1st(1st leg): 21/01/2016 20:00 2nd (2nd leg): 28/01/2016 19:00 Winner: Sevilla FC