1st(1st leg) CD Ebro - Valencia CF 1:2 (0:0)
2nd (2nd leg) Valencia CF - CD Ebro 1:0 (0:0)
1st(1st leg): 30/10/2018 18:30 2nd (2nd leg): 04/12/2018 18:30 Winner: Valencia CF
1st(1st leg) CD Lugo - Levante UD 1:1 (1:0)
2nd (2nd leg) Levante UD - CD Lugo 2:0 (0:0)
1st(1st leg): 30/10/2018 18:30 2nd (2nd leg): 06/12/2018 11:00 Winner: Levante UD
1st(1st leg) CD Leganés - Rayo Vallecano 2:2 (1:2)
2nd (2nd leg) Rayo Vallecano - CD Leganés 0:1 (0:1)
1st(1st leg): 30/10/2018 19:30 2nd (2nd leg): 04/12/2018 19:30 Winner: CD Leganés
1st(1st leg) UE Sant Andreu - Atlético Madrid 0:1 (0:1)
2nd (2nd leg) Atlético Madrid - UE Sant Andreu 4:0 (0:0)
1st(1st leg): 30/10/2018 20:30 2nd (2nd leg): 05/12/2018 18:30 Winner: Atlético Madrid
1st(1st leg) UD Melilla - Real Madrid 0:4 (0:2)
2nd (2nd leg) Real Madrid - UD Melilla 6:1 (3:0)
1st(1st leg): 31/10/2018 18:30 2nd (2nd leg): 06/12/2018 15:15 Winner: Real Madrid
1st(1st leg) RCD Mallorca - Real Valladolid 1:2 (0:2)
2nd (2nd leg) Real Valladolid - RCD Mallorca 2:1 (0:0)
1st(1st leg): 31/10/2018 19:30 2nd (2nd leg): 05/12/2018 20:30 Winner: Real Valladolid
1st(1st leg) Córdoba CF - Getafe CF 1:2 (1:1)
2nd (2nd leg) Getafe CF - Córdoba CF 5:1 (2:0)
1st(1st leg): 31/10/2018 19:30 2nd (2nd leg): 04/12/2018 18:30 Winner: Getafe CF
1st(1st leg) CD Alavés - Girona FC 2:2 (0:1)
2nd (2nd leg) Girona FC - CD Alavés 2:1 (0:0)
1st(1st leg): 31/10/2018 19:30 2nd (2nd leg): 05/12/2018 18:30 Winner: Girona FC
1st(1st leg) CD Leonesa - FC Barcelona 0:1 (0:0)
2nd (2nd leg) FC Barcelona - CD Leonesa 4:1 (3:0)
1st(1st leg): 31/10/2018 20:30 2nd (2nd leg): 05/12/2018 20:30 Winner: FC Barcelona
1st(1st leg) Sporting Gijón - SD Eibar 2:0 (0:0)
2nd (2nd leg) SD Eibar - Sporting Gijón 2:2 (0:2)
1st(1st leg): 01/11/2018 11:00 2nd (2nd leg): 06/12/2018 17:30 Winner: Sporting Gijón
1st(1st leg) CF Villanovense - Sevilla FC 0:0 (0:0)
2nd (2nd leg) Sevilla FC - CF Villanovense 1:0 (0:0)
1st(1st leg): 01/11/2018 15:15 2nd (2nd leg): 05/12/2018 19:30 Winner: Sevilla FC
1st(1st leg) RC Celta - Real Sociedad 1:1 (0:0)
2nd (2nd leg) Real Sociedad - RC Celta 2:0 (2:0)
1st(1st leg): 01/11/2018 15:15 2nd (2nd leg): 05/12/2018 19:30 Winner: Real Sociedad
1st(1st leg) UD Almería - Villarreal CF 3:3 (0:0)
2nd (2nd leg) Villarreal CF - UD Almería 8:0 (4:0)
1st(1st leg): 01/11/2018 17:30 2nd (2nd leg): 05/12/2018 19:30 Winner: Villarreal CF
1st(1st leg) Cádiz CF - Espanyol Barcelona 2:1 (2:1)
2nd (2nd leg) Espanyol Barcelona - Cádiz CF 1:0 (0:0)
1st(1st leg): 01/11/2018 17:30 2nd (2nd leg): 04/12/2018 20:30 Winner: Espanyol Barcelona
1st(1st leg) Racing Santander - Real Betis 0:1 (0:1)
2nd (2nd leg) Real Betis - Racing Santander 4:0 (1:0)
1st(1st leg): 01/11/2018 19:45 2nd (2nd leg): 06/12/2018 19:45 Winner: Real Betis
1st(1st leg) Athletic Bilbao - SD Huesca 4:0 (3:0)
2nd (2nd leg) SD Huesca - Athletic Bilbao 0:4 (0:1)
1st(1st leg): 28/11/2018 19:45 2nd (2nd leg): 06/12/2018 17:30 Winner: Athletic Bilbao