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| 1st(1st leg) | Rayo Vallecano | - | Real Betis | 1:2 (1:1) | ||
| 2nd (2nd leg) | Real Betis | - | Rayo Vallecano | 1:1 (0:0) | ||
| 1st(1st leg): 09/02/2022 20:00 | 2nd (2nd leg): 03/03/2022 20:00 | Winner: Real Betis | ||||
| 1st(1st leg) | Athletic Bilbao | - | Valencia CF | 1:1 (1:0) | ||
| 2nd (2nd leg) | Valencia CF | - | Athletic Bilbao | 1:0 (1:0) | ||
| 1st(1st leg): 10/02/2022 20:30 | 2nd (2nd leg): 02/03/2022 20:30 | Winner: Valencia CF | ||||
