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| 1st(1st leg) | CD Tenerife | - | UD Las Palmas | 1:0 (1:0) | ||
| 2nd (2nd leg) | UD Las Palmas | - | CD Tenerife | 1:2 (0:2) | ||
| 1st(1st leg): 01/06/2022 20:00 | 2nd (2nd leg): 04/06/2022 20:00 | Winner: CD Tenerife | ||||
| 1st(1st leg) | Girona FC | - | SD Eibar | 0:1 (0:1) | ||
| 2nd (2nd leg) | SD Eibar | - | Girona FC | 0:2 (0:1, 0:1) aet | ||
| 1st(1st leg): 02/06/2022 18:00 | 2nd (2nd leg): 05/06/2022 17:30 | Winner: Girona FC | ||||
