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| 1st(1st leg) | UD Melilla | - | CD Alavés | 1:1 | ||
| 2nd (2nd leg) | CD Alavés | - | UD Melilla | 1:0 | ||
| 1st(1st leg): 21/05/2011 17:00 | 2nd (2nd leg): 29/05/2011 17:00 | Winner: CD Alavés | ||||
| 1st(1st leg) | Real Madrid Castilla | - | CD Alcoyano | 0:2 | ||
| 2nd (2nd leg) | CD Alcoyano | - | Real Madrid Castilla | 2:2 | ||
| 1st(1st leg): 22/05/2011 11:00 | 2nd (2nd leg): 29/05/2011 18:00 | Winner: CD Alcoyano | ||||
| 1st(1st leg) | Orihuela CF | - | CD Guadalajara | 0:2 | ||
| 2nd (2nd leg) | CD Guadalajara | - | Orihuela CF | 1:1 | ||
| 1st(1st leg): 22/05/2011 16:00 | 2nd (2nd leg): 29/05/2011 18:30 | Winner: CD Guadalajara | ||||
| 1st(1st leg) | CD Leganés | - | CF Badalona | 2:1 | ||
| 2nd (2nd leg) | CF Badalona | - | CD Leganés | 1:0 | ||
| 1st(1st leg): 22/05/2011 18:00 | 2nd (2nd leg): 29/05/2011 18:00 | Winner: CF Badalona | ||||
| 1st(1st leg) | Real Unión | - | Sevilla Atlético | 2:1 | ||
| 2nd (2nd leg) | Sevilla Atlético | - | Real Unión | 3:0 | ||
| 1st(1st leg): 22/05/2011 18:00 | 2nd (2nd leg): 28/05/2011 17:00 | Winner: Sevilla Atlético | ||||
| 1st(1st leg) | Cádiz CF | - | CD Mirandés | 2:0 | ||
| 2nd (2nd leg) | CD Mirandés | - | Cádiz CF | 4:1 | ||
| 1st(1st leg): 22/05/2011 18:00 | 2nd (2nd leg): 29/05/2011 18:00 | Winner: CD Mirandés | ||||
