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| 1st(1st leg) | Feyenoord | - | Slavia Praha | 3:3 (1:1) | ||
| 2nd (2nd leg) | Slavia Praha | - | Feyenoord | 1:3 (1:1) | ||
| 1st(1st leg): 07/04/2022 17:45 | 2nd (2nd leg): 14/04/2022 20:00 | Winner: Feyenoord | ||||
| 1st(1st leg) | FK Bodø/Glimt | - | AS Roma | 2:1 (0:1) | ||
| 2nd (2nd leg) | AS Roma | - | FK Bodø/Glimt | 4:0 (3:0) | ||
| 1st(1st leg): 07/04/2022 20:00 | 2nd (2nd leg): 14/04/2022 20:00 | Winner: AS Roma | ||||
| 1st(1st leg) | Olympique Marseille | - | PAOK Saloniki | 2:1 (2:0) | ||
| 2nd (2nd leg) | PAOK Saloniki | - | Olympique Marseille | 0:1 (0:1) | ||
| 1st(1st leg): 07/04/2022 20:00 | 2nd (2nd leg): 14/04/2022 20:00 | Winner: Olympique Marseille | ||||
| 1st(1st leg) | Leicester City | - | PSV Eindhoven | 0:0 (0:0) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | Leicester City | 1:2 (1:0) | ||
| 1st(1st leg): 07/04/2022 20:00 | 2nd (2nd leg): 14/04/2022 17:45 | Winner: Leicester City | ||||
