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| 1st(1st leg) | KAA Gent | - | West Ham United | 1:1 (0:1) | ||
| 2nd (2nd leg) | West Ham United | - | KAA Gent | 4:1 (1:1) | ||
| 1st(1st leg): 13/04/2023 17:45 | 2nd (2nd leg): 20/04/2023 20:00 | Winner: West Ham United | ||||
| 1st(1st leg) | Lech Poznań | - | ACF Fiorentina | 1:4 (1:2) | ||
| 2nd (2nd leg) | ACF Fiorentina | - | Lech Poznań | 2:3 (0:1) | ||
| 1st(1st leg): 13/04/2023 20:00 | 2nd (2nd leg): 20/04/2023 17:45 | Winner: ACF Fiorentina | ||||
| 1st(1st leg) | RSC Anderlecht | - | AZ Alkmaar | 2:0 (1:0) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | RSC Anderlecht | 4:1 (2:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 13/04/2023 20:00 | 2nd (2nd leg): 20/04/2023 17:45 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | FC Basel | - | OGC Nice | 2:2 (1:2) | ||
| 2nd (2nd leg) | OGC Nice | - | FC Basel | 1:2 (1:0, 1:1) aet | ||
| 1st(1st leg): 13/04/2023 20:00 | 2nd (2nd leg): 20/04/2023 20:00 | Winner: FC Basel | ||||
