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| 1st(1st leg) | Viborg FF | - | B36 Tórshavn | 3:0 (1:0) | ||
| 2nd (2nd leg) | B36 Tórshavn | - | Viborg FF | 1:2 (0:0) | ||
| 1st(1st leg): 03/08/2022 18:00 | 2nd (2nd leg): 09/08/2022 19:00 | Winner: Viborg FF | ||||
| 1st(1st leg) | Riga FC | - | Gil Vicente | 1:1 (1:0) | ||
| 2nd (2nd leg) | Gil Vicente | - | Riga FC | 4:0 (3:0) | ||
| 1st(1st leg): 03/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 20:00 | Winner: Gil Vicente | ||||
| 1st(1st leg) | Wolfsberger AC | - | Gżira United | 0:0 (0:0) | ||
| 2nd (2nd leg) | Gżira United | - | Wolfsberger AC | 0:4 (0:2) | ||
| 1st(1st leg): 03/08/2022 18:30 | 2nd (2nd leg): 09/08/2022 17:00 | Winner: Wolfsberger AC | ||||
| 1st(1st leg) | FC DAC 1904 | - | FCSB | 0:1 (0:0) | ||
| 2nd (2nd leg) | FCSB | - | FC DAC 1904 | 1:0 (1:0) | ||
| 1st(1st leg): 03/08/2022 19:30 | 2nd (2nd leg): 11/08/2022 18:30 | Winner: FCSB | ||||
| 1st(1st leg) | Rīgas Futbola skola | - | Hibernians FC | 1:1 (0:1) | ||
| 2nd (2nd leg) | Hibernians FC | - | Rīgas Futbola skola | 1:3 (0:1) | ||
| 1st(1st leg): 04/08/2022 17:00 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: Rīgas Futbola skola | ||||
| 1st(1st leg) | Kuopion PS | - | BSC Young Boys | 0:2 (0:2) | ||
| 2nd (2nd leg) | BSC Young Boys | - | Kuopion PS | 3:0 (2:0) | ||
| 1st(1st leg): 04/08/2022 17:00 | 2nd (2nd leg): 11/08/2022 20:00 | Winner: BSC Young Boys | ||||
| 1st(1st leg) | Spartak Trnava | - | Raków Częstochowa | 0:2 (0:2) | ||
| 2nd (2nd leg) | Raków Częstochowa | - | Spartak Trnava | 1:0 (0:0) | ||
| 1st(1st leg): 04/08/2022 17:30 | 2nd (2nd leg): 11/08/2022 17:00 | Winner: Raków Częstochowa | ||||
| 1st(1st leg) | Paide Linnameeskond | - | RSC Anderlecht | 0:2 (0:2) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | Paide Linnameeskond | 3:0 (0:0) | ||
| 1st(1st leg): 04/08/2022 17:45 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: RSC Anderlecht | ||||
| 1st(1st leg) | Shakhter Soligorsk | - | CFR Cluj | 0:0 (0:0) | ||
| 2nd (2nd leg) | CFR Cluj | - | Shakhter Soligorsk | 1:0 (1:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 18:00 | Winner: CFR Cluj | ||||
| 1st(1st leg) | AIK Solna | - | KF Shkëndija 79 | 1:1 (1:1) | ||
| 2nd (2nd leg) | KF Shkëndija 79 | - | AIK Solna | 2:3 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: AIK Solna | ||||
| 1st(1st leg) | Lillestrøm SK | - | Royal Antwerp FC | 1:3 (1:1) | ||
| 2nd (2nd leg) | Royal Antwerp FC | - | Lillestrøm SK | 2:0 (1:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 18:30 | Winner: Royal Antwerp FC | ||||
| 1st(1st leg) | Viking FK | - | Sligo Rovers | 5:1 (2:0) | ||
| 2nd (2nd leg) | Sligo Rovers | - | Viking FK | 1:0 (1:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: Viking FK | ||||
| 1st(1st leg) | CSKA Sofia | - | St Patrick's Athletic | 0:1 (0:0) | ||
| 2nd (2nd leg) | St Patrick's Athletic | - | CSKA Sofia | 0:2 (0:1) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 19:45 | Winner: CSKA Sofia | ||||
| 1st(1st leg) | APOEL Nikosia | - | FK Kyzylzhar | 1:0 (1:0) | ||
| 2nd (2nd leg) | FK Kyzylzhar | - | APOEL Nikosia | 0:0 (0:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 14:30 | Winner: APOEL Nikosia | ||||
| 1st(1st leg) | Molde FK | - | Kisvárda FC | 3:0 (0:0) | ||
| 2nd (2nd leg) | Kisvárda FC | - | Molde FK | 2:1 (2:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 20:00 | Winner: Molde FK | ||||
| 1st(1st leg) | Neftçi PFK | - | Rapid Wien | 2:1 (1:0) | ||
| 2nd (2nd leg) | Rapid Wien | - | Neftçi PFK | 2:0 (0:0, 1:0) aet | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 19:30 | Winner: Rapid Wien | ||||
| 1st(1st leg) | Maccabi Tel Aviv | - | Aris Saloniki | 2:0 (1:0) | ||
| 2nd (2nd leg) | Aris Saloniki | - | Maccabi Tel Aviv | 2:1 (0:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: Maccabi Tel Aviv | ||||
| 1st(1st leg) | Slavia Praha | - | Panathinaikos | 2:0 (1:0) | ||
| 2nd (2nd leg) | Panathinaikos | - | Slavia Praha | 1:1 (0:0) | ||
| 1st(1st leg): 04/08/2022 18:00 | 2nd (2nd leg): 11/08/2022 18:30 | Winner: Slavia Praha | ||||
| 1st(1st leg) | Zorya Lugansk | - | CS Universitatea Craiova | 1:0 (0:0) | ||
| 2nd (2nd leg) | CS Universitatea Craiova | - | Zorya Lugansk | 3:0 (1:0) | ||
| 1st(1st leg): 04/08/2022 18:30 | 2nd (2nd leg): 11/08/2022 18:30 | Winner: CS Universitatea Craiova | ||||
| 1st(1st leg) | Hamrun Spartans | - | Levski Sofia | 0:1 (0:0) | ||
| 2nd (2nd leg) | Levski Sofia | - | Hamrun Spartans | 1:4 (0:0, 1:2, 1:2) pso | ||
| 1st(1st leg): 04/08/2022 18:30 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: Hamrun Spartans | ||||
| 1st(1st leg) | KF Ballkani | - | KÍ Klaksvík | 3:2 (2:0) | ||
| 2nd (2nd leg) | KÍ Klaksvík | - | KF Ballkani | 3:4 (0:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 04/08/2022 19:00 | 2nd (2nd leg): 11/08/2022 19:00 | Winner: KF Ballkani | ||||
| 1st(1st leg) | FC Vaduz | - | Konyaspor | 1:1 (0:0) | ||
| 2nd (2nd leg) | Konyaspor | - | FC Vaduz | 2:4 (1:2) | ||
| 1st(1st leg): 04/08/2022 19:00 | 2nd (2nd leg): 11/08/2022 18:00 | Winner: FC Vaduz | ||||
| 1st(1st leg) | FC Lugano | - | Hapoel Be'er Sheva | 0:2 (0:1) | ||
| 2nd (2nd leg) | Hapoel Be'er Sheva | - | FC Lugano | 3:1 (0:0) | ||
| 1st(1st leg): 04/08/2022 19:00 | 2nd (2nd leg): 11/08/2022 18:15 | Winner: Hapoel Be'er Sheva | ||||
| 1st(1st leg) | Sepsi OSK | - | Djurgårdens IF | 1:3 (0:2) | ||
| 2nd (2nd leg) | Djurgårdens IF | - | Sepsi OSK | 3:1 (2:1) | ||
| 1st(1st leg): 04/08/2022 19:00 | 2nd (2nd leg): 11/08/2022 18:00 | Winner: Djurgårdens IF | ||||
| 1st(1st leg) | FK Čukarički | - | FC Twente | 1:3 (0:3) | ||
| 2nd (2nd leg) | FC Twente | - | FK Čukarički | 4:1 (2:1) | ||
| 1st(1st leg): 04/08/2022 19:00 | 2nd (2nd leg): 11/08/2022 18:00 | Winner: FC Twente | ||||
| 1st(1st leg) | Brøndby IF | - | FC Basel | 1:0 (0:0) | ||
| 2nd (2nd leg) | FC Basel | - | Brøndby IF | 3:1 (2:1, 2:1, 2:1) pso | ||
| 1st(1st leg): 04/08/2022 19:30 | 2nd (2nd leg): 11/08/2022 18:15 | Winner: FC Basel | ||||
| 1st(1st leg) | Víkingur Reykjavík | - | Lech Poznań | 1:0 (1:0) | ||
| 2nd (2nd leg) | Lech Poznań | - | Víkingur Reykjavík | 4:1 (2:0, 2:1) aet | ||
| 1st(1st leg): 04/08/2022 19:45 | 2nd (2nd leg): 11/08/2022 19:30 | Winner: Lech Poznań | ||||
| 1st(1st leg) | Breiðablik | - | İstanbul Başakşehir | 1:3 (0:1) | ||
| 2nd (2nd leg) | İstanbul Başakşehir | - | Breiðablik | 3:0 (1:0) | ||
| 1st(1st leg): 04/08/2022 19:45 | 2nd (2nd leg): 11/08/2022 18:45 | Winner: İstanbul Başakşehir | ||||
| 1st(1st leg) | Fehérvár FC | - | CS Petrocub | 5:0 (3:0) | ||
| 2nd (2nd leg) | CS Petrocub | - | Fehérvár FC | 1:2 (1:2) | ||
| 1st(1st leg): 04/08/2022 19:55 | 2nd (2nd leg): 11/08/2022 18:00 | Winner: Fehérvár FC | ||||
| 1st(1st leg) | Zrinjski Mostar | - | Tobyl Kostanay | 1:0 (0:0) | ||
| 2nd (2nd leg) | Tobyl Kostanay | - | Zrinjski Mostar | 1:1 (0:1) | ||
| 1st(1st leg): 04/08/2022 20:00 | 2nd (2nd leg): 11/08/2022 15:00 | Winner: Zrinjski Mostar | ||||
| 1st(1st leg) | Hajduk Split | - | Vitória Guimarães | 3:1 (0:0) | ||
| 2nd (2nd leg) | Vitória Guimarães | - | Hajduk Split | 1:0 (1:0) | ||
| 1st(1st leg): 04/08/2022 20:00 | 2nd (2nd leg): 10/08/2022 17:00 | Winner: Hajduk Split | ||||
| 1st(1st leg) | Dundee United | - | AZ Alkmaar | 1:0 (0:0) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | Dundee United | 7:0 (5:0) | ||
| 1st(1st leg): 04/08/2022 20:00 | 2nd (2nd leg): 11/08/2022 20:00 | Winner: AZ Alkmaar | ||||
