 |
 |
|
| 1st(1st leg) | Djurgårdens IF | - | APOEL Nikosia | 3:0 (1:0) | ||
| 2nd (2nd leg) | APOEL Nikosia | - | Djurgårdens IF | 3:2 (2:0) | ||
| 1st(1st leg): 17/08/2022 17:45 | 2nd (2nd leg): 23/08/2022 17:00 | Winner: Djurgårdens IF | ||||
| 1st(1st leg) | Raków Częstochowa | - | Slavia Praha | 2:1 (1:0) | ||
| 2nd (2nd leg) | Slavia Praha | - | Raków Częstochowa | 2:0 (0:0, 1:0) aet | ||
| 1st(1st leg): 18/08/2022 17:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: Slavia Praha | ||||
| 1st(1st leg) | Rīgas Futbola skola | - | Linfield FC | 2:2 (0:1) | ||
| 2nd (2nd leg) | Linfield FC | - | Rīgas Futbola skola | 2:4 (0:0, 0:0, 1:1) pso | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 19:45 | Winner: Rīgas Futbola skola | ||||
| 1st(1st leg) | BSC Young Boys | - | RSC Anderlecht | 0:1 (0:0) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | BSC Young Boys | 3:1 (0:1, 0:1, 0:1) pso | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 19:00 | Winner: RSC Anderlecht | ||||
| 1st(1st leg) | 1. FC Slovácko | - | AIK Solna | 3:0 (1:0) | ||
| 2nd (2nd leg) | AIK Solna | - | 1. FC Slovácko | 0:1 (0:0) | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: 1. FC Slovácko | ||||
| 1st(1st leg) | Molde FK | - | Wolfsberger AC | 0:1 (0:1) | ||
| 2nd (2nd leg) | Wolfsberger AC | - | Molde FK | 0:4 (0:2) | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: Molde FK | ||||
| 1st(1st leg) | CSKA Sofia | - | FC Basel | 1:0 (0:0) | ||
| 2nd (2nd leg) | FC Basel | - | CSKA Sofia | 2:0 (0:0) | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: FC Basel | ||||
| 1st(1st leg) | Maccabi Tel Aviv | - | OGC Nice | 1:0 (0:0) | ||
| 2nd (2nd leg) | OGC Nice | - | Maccabi Tel Aviv | 2:0 (1:0, 1:0) aet | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 19:00 | Winner: OGC Nice | ||||
| 1st(1st leg) | CS Universitatea Craiova | - | Hapoel Be'er Sheva | 1:1 (0:0) | ||
| 2nd (2nd leg) | Hapoel Be'er Sheva | - | CS Universitatea Craiova | 4:3 (0:0, 0:0, 1:1) pso | ||
| 1st(1st leg): 18/08/2022 18:30 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: Hapoel Be'er Sheva | ||||
| 1st(1st leg) | İstanbul Başakşehir | - | Royal Antwerp FC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Royal Antwerp FC | - | İstanbul Başakşehir | 1:3 (0:1) | ||
| 1st(1st leg): 18/08/2022 18:45 | 2nd (2nd leg): 25/08/2022 19:45 | Winner: İstanbul Başakşehir | ||||
| 1st(1st leg) | Zrinjski Mostar | - | Slovan Bratislava | 1:0 (0:0) | ||
| 2nd (2nd leg) | Slovan Bratislava | - | Zrinjski Mostar | 6:5 (0:0, 1:0, 2:1) pso | ||
| 1st(1st leg): 18/08/2022 19:00 | 2nd (2nd leg): 25/08/2022 19:30 | Winner: Slovan Bratislava | ||||
| 1st(1st leg) | FC Vaduz | - | Rapid Wien | 1:1 (1:0) | ||
| 2nd (2nd leg) | Rapid Wien | - | FC Vaduz | 0:1 (0:1) | ||
| 1st(1st leg): 18/08/2022 19:00 | 2nd (2nd leg): 25/08/2022 20:00 | Winner: FC Vaduz | ||||
| 1st(1st leg) | NK Maribor | - | CFR Cluj | 0:0 (0:0) | ||
| 2nd (2nd leg) | CFR Cluj | - | NK Maribor | 1:0 (0:0) | ||
| 1st(1st leg): 18/08/2022 19:15 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: CFR Cluj | ||||
| 1st(1st leg) | Lech Poznań | - | F91 Dudelange | 2:0 (1:0) | ||
| 2nd (2nd leg) | F91 Dudelange | - | Lech Poznań | 1:1 (1:0) | ||
| 1st(1st leg): 18/08/2022 19:30 | 2nd (2nd leg): 25/08/2022 19:30 | Winner: Lech Poznań | ||||
| 1st(1st leg) | FCSB | - | Viking FK | 1:2 (1:2) | ||
| 2nd (2nd leg) | Viking FK | - | FCSB | 1:3 (1:1) | ||
| 1st(1st leg): 18/08/2022 19:30 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: FCSB | ||||
| 1st(1st leg) | 1. FC Köln | - | Fehérvár FC | 1:2 (1:2) | ||
| 2nd (2nd leg) | Fehérvár FC | - | 1. FC Köln | 0:3 (0:1) | ||
| 1st(1st leg): 18/08/2022 19:30 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | West Ham United | - | Viborg FF | 3:1 (1:0) | ||
| 2nd (2nd leg) | Viborg FF | - | West Ham United | 0:3 (0:1) | ||
| 1st(1st leg): 18/08/2022 19:45 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: West Ham United | ||||
| 1st(1st leg) | Villarreal CF | - | Hajduk Split | 4:2 (4:1) | ||
| 2nd (2nd leg) | Hajduk Split | - | Villarreal CF | 0:2 (0:1) | ||
| 1st(1st leg): 18/08/2022 19:45 | 2nd (2nd leg): 25/08/2022 20:00 | Winner: Villarreal CF | ||||
| 1st(1st leg) | KF Shkupi | - | KF Ballkani | 1:2 (1:1) | ||
| 2nd (2nd leg) | KF Ballkani | - | KF Shkupi | 1:0 (0:0) | ||
| 1st(1st leg): 18/08/2022 20:00 | 2nd (2nd leg): 25/08/2022 19:00 | Winner: KF Ballkani | ||||
| 1st(1st leg) | AZ Alkmaar | - | Gil Vicente | 4:0 (1:0) | ||
| 2nd (2nd leg) | Gil Vicente | - | AZ Alkmaar | 1:2 (0:0) | ||
| 1st(1st leg): 18/08/2022 20:00 | 2nd (2nd leg): 25/08/2022 20:00 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | Partizan | - | Hamrun Spartans | 4:1 (3:0) | ||
| 2nd (2nd leg) | Hamrun Spartans | - | Partizan | 3:3 (1:1) | ||
| 1st(1st leg): 18/08/2022 20:00 | 2nd (2nd leg): 25/08/2022 19:00 | Winner: Partizan | ||||
| 1st(1st leg) | ACF Fiorentina | - | FC Twente | 2:1 (2:0) | ||
| 2nd (2nd leg) | FC Twente | - | ACF Fiorentina | 0:0 (0:0) | ||
| 1st(1st leg): 18/08/2022 20:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: ACF Fiorentina | ||||
