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| 1st(1st leg) | Fulham FC | - | VfL Wolfsburg | 2:1 (0:0) | ||
| 2nd (2nd leg) | VfL Wolfsburg | - | Fulham FC | 0:1 (0:1) | ||
| 1st(1st leg): 01/04/2010 20:05 | 2nd (2nd leg): 08/04/2010 20:05 | Winner: Fulham FC | ||||
| 1st(1st leg) | Hamburger SV | - | Standard Liège | 2:1 (2:1) | ||
| 2nd (2nd leg) | Standard Liège | - | Hamburger SV | 1:3 (1:2) | ||
| 1st(1st leg): 01/04/2010 20:05 | 2nd (2nd leg): 08/04/2010 20:05 | Winner: Hamburger SV | ||||
| 1st(1st leg) | Valencia CF | - | Atlético Madrid | 2:2 (0:0) | ||
| 2nd (2nd leg) | Atlético Madrid | - | Valencia CF | 0:0 (0:0) | ||
| 1st(1st leg): 01/04/2010 20:05 | 2nd (2nd leg): 08/04/2010 20:05 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | SL Benfica | - | Liverpool FC | 2:1 (0:1) | ||
| 2nd (2nd leg) | Liverpool FC | - | SL Benfica | 4:1 (2:0) | ||
| 1st(1st leg): 01/04/2010 20:05 | 2nd (2nd leg): 08/04/2010 20:05 | Winner: Liverpool FC | ||||
