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| 1st(1st leg) | CSKA Moskva | - | FC Porto | 0:1 (0:0) | ||
| 2nd (2nd leg) | FC Porto | - | CSKA Moskva | 2:1 (2:1) | ||
| 1st(1st leg): 10/03/2011 18:00 | 2nd (2nd leg): 17/03/2011 20:05 | Winner: FC Porto | ||||
| 1st(1st leg) | PSV Eindhoven | - | Rangers FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Rangers FC | - | PSV Eindhoven | 0:1 (0:1) | ||
| 1st(1st leg): 10/03/2011 18:00 | 2nd (2nd leg): 17/03/2011 20:05 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | Bayer Leverkusen | - | Villarreal CF | 2:3 (1:1) | ||
| 2nd (2nd leg) | Villarreal CF | - | Bayer Leverkusen | 2:1 (1:0) | ||
| 1st(1st leg): 10/03/2011 18:00 | 2nd (2nd leg): 17/03/2011 20:05 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Sporting Braga | - | Liverpool FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Liverpool FC | - | Sporting Braga | 0:0 (0:0) | ||
| 1st(1st leg): 10/03/2011 18:00 | 2nd (2nd leg): 17/03/2011 20:05 | Winner: Sporting Braga | ||||
| 1st(1st leg) | SL Benfica | - | Paris Saint-Germain | 2:1 (1:1) | ||
| 2nd (2nd leg) | Paris Saint-Germain | - | SL Benfica | 1:1 (1:1) | ||
| 1st(1st leg): 10/03/2011 20:05 | 2nd (2nd leg): 17/03/2011 18:00 | Winner: SL Benfica | ||||
| 1st(1st leg) | Dinamo Kiev | - | Manchester City | 2:0 (1:0) | ||
| 2nd (2nd leg) | Manchester City | - | Dinamo Kiev | 1:0 (1:0) | ||
| 1st(1st leg): 10/03/2011 20:05 | 2nd (2nd leg): 17/03/2011 18:00 | Winner: Dinamo Kiev | ||||
| 1st(1st leg) | FC Twente | - | Zenit St. Petersburg | 3:0 (1:0) | ||
| 2nd (2nd leg) | Zenit St. Petersburg | - | FC Twente | 2:0 (2:0) | ||
| 1st(1st leg): 10/03/2011 20:05 | 2nd (2nd leg): 17/03/2011 18:00 | Winner: FC Twente | ||||
| 1st(1st leg) | AFC Ajax | - | Spartak Moskva | 0:1 (0:0) | ||
| 2nd (2nd leg) | Spartak Moskva | - | AFC Ajax | 3:0 (2:0) | ||
| 1st(1st leg): 10/03/2011 20:05 | 2nd (2nd leg): 17/03/2011 18:00 | Winner: Spartak Moskva | ||||
