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| 1st(1st leg) | RB Leipzig | - | Olympique Marseille | 1:0 (1:0) | ||
| 2nd (2nd leg) | Olympique Marseille | - | RB Leipzig | 5:2 (3:1) | ||
| 1st(1st leg): 05/04/2018 20:05 | 2nd (2nd leg): 12/04/2018 20:05 | Winner: Olympique Marseille | ||||
| 1st(1st leg) | Arsenal FC | - | CSKA Moskva | 4:1 (4:1) | ||
| 2nd (2nd leg) | CSKA Moskva | - | Arsenal FC | 2:2 (1:0) | ||
| 1st(1st leg): 05/04/2018 20:05 | 2nd (2nd leg): 12/04/2018 20:05 | Winner: Arsenal FC | ||||
| 1st(1st leg) | Atlético Madrid | - | Sporting CP | 2:0 (2:0) | ||
| 2nd (2nd leg) | Sporting CP | - | Atlético Madrid | 1:0 (1:0) | ||
| 1st(1st leg): 05/04/2018 20:05 | 2nd (2nd leg): 12/04/2018 20:05 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | Lazio Roma | - | RB Salzburg | 4:2 (1:1) | ||
| 2nd (2nd leg) | RB Salzburg | - | Lazio Roma | 4:1 (0:0) | ||
| 1st(1st leg): 05/04/2018 20:05 | 2nd (2nd leg): 12/04/2018 20:05 | Winner: RB Salzburg | ||||
