1st(1st leg) Fenerbahçe - Zenit St. Petersburg 1:0 (1:0)
2nd (2nd leg) Zenit St. Petersburg - Fenerbahçe 3:1 (2:1)
1st(1st leg): 12/02/2019 17:55 2nd (2nd leg): 21/02/2019 17:55 Winner: Zenit St. Petersburg
1st(1st leg) Rapid Wien - Inter 0:1 (0:1)
2nd (2nd leg) Inter - Rapid Wien 4:0 (2:0)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 20:00 Winner: Inter
1st(1st leg) Slavia Praha - KRC Genk 0:0 (0:0)
2nd (2nd leg) KRC Genk - Slavia Praha 1:4 (1:1)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 20:00 Winner: Slavia Praha
1st(1st leg) FK Krasnodar - Bayer Leverkusen 0:0 (0:0)
2nd (2nd leg) Bayer Leverkusen - FK Krasnodar 1:1 (0:0)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 20:00 Winner: FK Krasnodar
1st(1st leg) Stade Rennes - Real Betis 3:3 (3:1)
2nd (2nd leg) Real Betis - Stade Rennes 1:3 (1:2)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 20:00 Winner: Stade Rennes
1st(1st leg) Olympiakos Piräus - Dinamo Kiev 2:2 (2:1)
2nd (2nd leg) Dinamo Kiev - Olympiakos Piräus 1:0 (1:0)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 20:00 Winner: Dinamo Kiev
1st(1st leg) Lazio Roma - Sevilla FC 0:1 (0:1)
2nd (2nd leg) Sevilla FC - Lazio Roma 2:0 (1:0)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 20/02/2019 17:00 Winner: Sevilla FC
1st(1st leg) BATE Borisov - Arsenal FC 1:0 (1:0)
2nd (2nd leg) Arsenal FC - BATE Borisov 3:0 (2:0)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 17:55 Winner: Arsenal FC
1st(1st leg) Galatasaray - SL Benfica 1:2 (0:1)
2nd (2nd leg) SL Benfica - Galatasaray 0:0 (0:0)
1st(1st leg): 14/02/2019 17:55 2nd (2nd leg): 21/02/2019 20:00 Winner: SL Benfica
1st(1st leg) Viktoria Plzeň - Dinamo Zagreb 2:1 (0:1)
2nd (2nd leg) Dinamo Zagreb - Viktoria Plzeň 3:0 (2:0)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 17:55 Winner: Dinamo Zagreb
1st(1st leg) Club Brugge KV - RB Salzburg 2:1 (0:1)
2nd (2nd leg) RB Salzburg - Club Brugge KV 4:0 (3:0)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 17:55 Winner: RB Salzburg
1st(1st leg) FC Zürich - SSC Napoli 1:3 (0:2)
2nd (2nd leg) SSC Napoli - FC Zürich 2:0 (1:0)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 17:55 Winner: SSC Napoli
1st(1st leg) Malmö FF - Chelsea FC 1:2 (0:1)
2nd (2nd leg) Chelsea FC - Malmö FF 3:0 (0:0)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 20:00 Winner: Chelsea FC
1st(1st leg) Shakhtar Donetsk - Eintracht Frankfurt 2:2 (1:1)
2nd (2nd leg) Eintracht Frankfurt - Shakhtar Donetsk 4:1 (2:0)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 17:55 Winner: Eintracht Frankfurt
1st(1st leg) Celtic FC - Valencia CF 0:2 (0:1)
2nd (2nd leg) Valencia CF - Celtic FC 1:0 (0:0)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 17:55 Winner: Valencia CF
1st(1st leg) Sporting CP - Villarreal CF 0:1 (0:1)
2nd (2nd leg) Villarreal CF - Sporting CP 1:1 (0:1)
1st(1st leg): 14/02/2019 20:00 2nd (2nd leg): 21/02/2019 17:55 Winner: Villarreal CF