1st(1st leg) FC Porto - Olympique Lyon 0:1 (0:0)
2nd (2nd leg) Olympique Lyon - FC Porto 1:1 (1:1)
1st(1st leg): 09/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: Olympique Lyon
1st(1st leg) Real Betis - Eintracht Frankfurt 1:2 (1:2)
2nd (2nd leg) Eintracht Frankfurt - Real Betis 1:1 (0:0, 0:1) aet
1st(1st leg): 09/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: Eintracht Frankfurt
1st(1st leg) RB Leipzig - Spartak Moskva dnp
2nd (2nd leg) Spartak Moskva - RB Leipzig dnp
1st(1st leg): 10/03/2022 2nd (2nd leg): 17/03/2022 Winner: RB Leipzig
1st(1st leg) Sevilla FC - West Ham United 1:0 (0:0)
2nd (2nd leg) West Ham United - Sevilla FC 2:0 (1:0, 1:0) aet
1st(1st leg): 10/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: West Ham United
1st(1st leg) Rangers FC - Crvena Zvezda 3:0 (2:0)
2nd (2nd leg) Crvena Zvezda - Rangers FC 2:1 (1:0)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: Rangers FC
1st(1st leg) Sporting Braga - AS Monaco 2:0 (1:0)
2nd (2nd leg) AS Monaco - Sporting Braga 1:1 (0:1)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: Sporting Braga
1st(1st leg) Atalanta - Bayer Leverkusen 3:2 (2:1)
2nd (2nd leg) Bayer Leverkusen - Atalanta 0:1 (0:0)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: Atalanta
1st(1st leg) FC Barcelona - Galatasaray 0:0 (0:0)
2nd (2nd leg) Galatasaray - FC Barcelona 1:2 (1:1)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: FC Barcelona