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| 1st(1st leg) | RB Leipzig | - | Rangers FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Rangers FC | - | RB Leipzig | 3:1 (2:0) | ||
| 1st(1st leg): 28/04/2022 20:00 | 2nd (2nd leg): 05/05/2022 20:00 | Winner: Rangers FC | ||||
| 1st(1st leg) | West Ham United | - | Eintracht Frankfurt | 1:2 (1:1) | ||
| 2nd (2nd leg) | Eintracht Frankfurt | - | West Ham United | 1:0 (1:0) | ||
| 1st(1st leg): 28/04/2022 20:00 | 2nd (2nd leg): 05/05/2022 20:00 | Winner: Eintracht Frankfurt | ||||
