 |
 |
|
| 1st(1st leg) | Neftçi PFK | - | HJK Helsinki | 2:2 (0:0) | ||
| 2nd (2nd leg) | HJK Helsinki | - | Neftçi PFK | 3:0 (0:0) | ||
| 1st(1st leg): 03/08/2021 18:00 | 2nd (2nd leg): 12/08/2021 17:00 | Winner: HJK Helsinki | ||||
| 1st(1st leg) | FK Kairat | - | FC Alashkert | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Alashkert | - | FK Kairat | 3:2 (1:1, 2:2) aet | ||
| 1st(1st leg): 05/08/2021 15:00 | 2nd (2nd leg): 12/08/2021 16:00 | Winner: FC Alashkert | ||||
| 1st(1st leg) | FK Jablonec | - | Celtic FC | 2:4 (1:2) | ||
| 2nd (2nd leg) | Celtic FC | - | FK Jablonec | 3:0 (1:0) | ||
| 1st(1st leg): 05/08/2021 16:45 | 2nd (2nd leg): 12/08/2021 19:45 | Winner: Celtic FC | ||||
| 1st(1st leg) | Omonia Nikosia | - | FC Flora | 1:0 (1:0) | ||
| 2nd (2nd leg) | FC Flora | - | Omonia Nikosia | 4:5 (0:1, 2:1, 2:1) pso | ||
| 1st(1st leg): 05/08/2021 17:00 | 2nd (2nd leg): 10/08/2021 17:00 | Winner: Omonia Nikosia | ||||
| 1st(1st leg) | Lincoln Red Imps | - | Slovan Bratislava | 1:3 (0:1) | ||
| 2nd (2nd leg) | Slovan Bratislava | - | Lincoln Red Imps | 1:1 (1:0) | ||
| 1st(1st leg): 05/08/2021 17:00 | 2nd (2nd leg): 10/08/2021 19:30 | Winner: Slovan Bratislava | ||||
| 1st(1st leg) | NŠ Mura | - | FK Žalgiris | 0:0 (0:0) | ||
| 2nd (2nd leg) | FK Žalgiris | - | NŠ Mura | 0:1 (0:1) | ||
| 1st(1st leg): 05/08/2021 19:00 | 2nd (2nd leg): 12/08/2021 18:00 | Winner: NŠ Mura | ||||
| 1st(1st leg) | Galatasaray | - | St. Johnstone FC | 1:1 (0:0) | ||
| 2nd (2nd leg) | St. Johnstone FC | - | Galatasaray | 2:4 (1:1) | ||
| 1st(1st leg): 05/08/2021 19:00 | 2nd (2nd leg): 12/08/2021 19:00 | Winner: Galatasaray | ||||
| 1st(1st leg) | Rapid Wien | - | Anorthosis Famagusta | 3:0 (1:0) | ||
| 2nd (2nd leg) | Anorthosis Famagusta | - | Rapid Wien | 2:1 (1:0) | ||
| 1st(1st leg): 05/08/2021 19:30 | 2nd (2nd leg): 12/08/2021 18:00 | Winner: Rapid Wien | ||||
