1st(1st leg) AEK Larnaca - Partizan 2:1 (1:1)
2nd (2nd leg) Partizan - AEK Larnaca 2:2 (1:0)
1st(1st leg): 04/08/2022 17:00 2nd (2nd leg): 11/08/2022 20:00 Winner: AEK Larnaca
1st(1st leg) Malmö FF - F91 Dudelange 3:0 (0:0)
2nd (2nd leg) F91 Dudelange - Malmö FF 2:2 (0:0)
1st(1st leg): 04/08/2022 18:00 2nd (2nd leg): 11/08/2022 19:00 Winner: Malmö FF
1st(1st leg) Fenerbahçe - 1. FC Slovácko 3:0 (2:0)
2nd (2nd leg) 1. FC Slovácko - Fenerbahçe 1:1 (0:0)
1st(1st leg): 04/08/2022 18:00 2nd (2nd leg): 11/08/2022 18:00 Winner: Fenerbahçe
1st(1st leg) NK Maribor - HJK Helsinki 0:2 (0:0)
2nd (2nd leg) HJK Helsinki - NK Maribor 1:0 (0:0)
1st(1st leg): 04/08/2022 19:15 2nd (2nd leg): 11/08/2022 17:00 Winner: HJK Helsinki
1st(1st leg) Linfield FC - FC Zürich 0:2 (0:1)
2nd (2nd leg) FC Zürich - Linfield FC 3:0 (2:0)
1st(1st leg): 04/08/2022 19:45 2nd (2nd leg): 11/08/2022 18:00 Winner: FC Zürich
1st(1st leg) Shamrock Rovers - KF Shkupi 3:1 (2:0)
2nd (2nd leg) KF Shkupi - Shamrock Rovers 1:2 (0:0)
1st(1st leg): 04/08/2022 20:00 2nd (2nd leg): 09/08/2022 20:00 Winner: Shamrock Rovers
1st(1st leg) Olympiakos Piraeus - Slovan Bratislava 1:1 (0:0)
2nd (2nd leg) Slovan Bratislava - Olympiakos Piraeus 3:4 (0:0, 1:1, 2:2) pso
1st(1st leg): 04/08/2022 20:00 2nd (2nd leg): 11/08/2022 19:30 Winner: Olympiakos Piraeus