1st(1st leg) Standard Liège - Brøndby IF 0:2 (0:2)
2nd (2nd leg) Brøndby IF - Standard Liège 3:4 (3:1)
1st(1st leg): 27/09/2011 13:00 2nd (2nd leg): 06/10/2011 17:30 Winner: Brøndby IF
1st(1st leg) ASA Tel Aviv - ASD Torres Calcio 0:2 (0:0)
2nd (2nd leg) ASD Torres Calcio - ASA Tel Aviv 3:2 (1:2)
1st(1st leg): 27/09/2011 16:00 2nd (2nd leg): 05/10/2011 11:00 Winner: ASD Torres Calcio
1st(1st leg) CSHVSM Almaty - SV Neulengbach 2:1 (1:1)
2nd (2nd leg) SV Neulengbach - CSHVSM Almaty 5:0 (1:0)
1st(1st leg): 28/09/2011 13:00 2nd (2nd leg): 05/10/2011 19:00 Winner: SV Neulengbach
1st(1st leg) Olimpia Cluj - Olympique Lyon 0:9 (0:8)
2nd (2nd leg) Olympique Lyon - Olimpia Cluj 3:0 (1:0)
1st(1st leg): 28/09/2011 14:30 2nd (2nd leg): 05/10/2011 18:00 Winner: Olympique Lyon
1st(1st leg) Apollon Limassol - AC Sparta Praha 2:2 (1:1)
2nd (2nd leg) AC Sparta Praha - Apollon Limassol 2:1 (2:1)
1st(1st leg): 28/09/2011 14:30 2nd (2nd leg): 05/10/2011 14:30 Winner: AC Sparta Praha
1st(1st leg) PK-35 Vantaa - Rayo Vallecano 1:4 (0:2)
2nd (2nd leg) Rayo Vallecano - PK-35 Vantaa 3:0 (1:0)
1st(1st leg): 28/09/2011 17:00 2nd (2nd leg): 06/10/2011 18:00 Winner: Rayo Vallecano
1st(1st leg) ŽNK Osijek - Kopparbergs/Göteborg FC 0:4 (0:2)
2nd (2nd leg) Kopparbergs/Göteborg FC - ŽNK Osijek 7:0 (2:0)
1st(1st leg): 28/09/2011 17:00 2nd (2nd leg): 06/10/2011 18:00 Winner: Kopparbergs/Göteborg FC
1st(1st leg) Þór/KA - Turbine Potsdam 0:6 (0:2)
2nd (2nd leg) Turbine Potsdam - Þór/KA 8:2 (4:1)
1st(1st leg): 28/09/2011 17:15 2nd (2nd leg): 05/10/2011 18:00 Winner: Turbine Potsdam
1st(1st leg) FC Twente - WFC Rossiyanka 0:2 (0:0)
2nd (2nd leg) WFC Rossiyanka - FC Twente 1:0 (0:0)
1st(1st leg): 28/09/2011 18:00 2nd (2nd leg): 06/10/2011 13:00 Winner: WFC Rossiyanka
1st(1st leg) Stabæk FK - 1. FFC Frankfurt 1:0 (0:0)
2nd (2nd leg) 1. FFC Frankfurt - Stabæk FK 4:1 (2:0)
1st(1st leg): 28/09/2011 18:00 2nd (2nd leg): 05/10/2011 14:00 Winner: 1. FFC Frankfurt
1st(1st leg) BSC Young Boys - Fortuna Hjørring 0:3 (0:1)
2nd (2nd leg) Fortuna Hjørring - BSC Young Boys 2:1 (0:1)
1st(1st leg): 28/09/2011 19:00 2nd (2nd leg): 05/10/2011 18:00 Winner: Fortuna Hjørring
1st(1st leg) Peamount United - Paris Saint-Germain 0:2 (0:0)
2nd (2nd leg) Paris Saint-Germain - Peamount United 3:0 (0:0)
1st(1st leg): 28/09/2011 19:45 2nd (2nd leg): 05/10/2011 16:00 Winner: Paris Saint-Germain
1st(1st leg) FC Bobruichanka - Arsenal LFC 0:4 (0:1)
2nd (2nd leg) Arsenal LFC - FC Bobruichanka 6:0 (3:0)
1st(1st leg): 29/09/2011 13:00 2nd (2nd leg): 05/10/2011 16:00 Winner: Arsenal LFC
1st(1st leg) Bristol Academy WFC - Energy Voronezh 1:1 (0:0)
2nd (2nd leg) Energy Voronezh - Bristol Academy WFC 4:2 (2:1)
1st(1st leg): 29/09/2011 19:30 2nd (2nd leg): 05/10/2011 16:00 Winner: Energy Voronezh
1st(1st leg) Glasgow City FC - Valur Reykjavik 1:1 (1:0)
2nd (2nd leg) Valur Reykjavik - Glasgow City FC 0:3 (0:1)
1st(1st leg): 29/09/2011 19:45 2nd (2nd leg): 06/10/2011 17:00 Winner: Glasgow City FC
1st(1st leg) UPC Tavagnacco - LdB FC Malmö 2:1 (2:0)
2nd (2nd leg) LdB FC Malmö - UPC Tavagnacco 5:0 (2:0)
1st(1st leg): 29/09/2011 20:00 2nd (2nd leg): 06/10/2011 18:00 Winner: LdB FC Malmö