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| 1st(1st leg) | AE Lárissa | - | Asteras Tripolis | 0:3 (0:1) | ||
| 2nd (2nd leg) | Asteras Tripolis | - | AE Lárissa | 3:0 (2:0) | ||
| 1st(1st leg): 05/01/2016 15:15 | 2nd (2nd leg): 13/01/2016 15:15 | Winner: Asteras Tripolis | ||||
| 1st(1st leg) | Veria FC | - | AEP Iraklis FC | 0:1 (0:0) | ||
| 2nd (2nd leg) | AEP Iraklis FC | - | Veria FC | 1:0 (0:0) | ||
| 1st(1st leg): 05/01/2016 17:30 | 2nd (2nd leg): 13/01/2016 13:00 | Winner: AEP Iraklis FC | ||||
| 1st(1st leg) | Platanias Chanion | - | Atromitos | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atromitos | - | Platanias Chanion | 2:1 (1:1) | ||
| 1st(1st leg): 06/01/2016 13:00 | 2nd (2nd leg): 12/01/2016 17:30 | Winner: Atromitos | ||||
| 1st(1st leg) | Ergotelis | - | Panionios GSS | 0:1 (0:1) | ||
| 2nd (2nd leg) | Panionios GSS | - | Ergotelis | 1:0 (1:0) | ||
| 1st(1st leg): 06/01/2016 15:15 | 2nd (2nd leg): 14/01/2016 13:00 | Winner: Panionios GSS | ||||
| 1st(1st leg) | Levadiakos | - | AEK Athen | 0:1 (0:1) | ||
| 2nd (2nd leg) | AEK Athen | - | Levadiakos | 2:0 (1:0) | ||
| 1st(1st leg): 06/01/2016 15:15 | 2nd (2nd leg): 13/01/2016 15:15 | Winner: AEK Athen | ||||
| 1st(1st leg) | AEL Kalloni | - | PAOK Saloniki | 2:1 (1:0) | ||
| 2nd (2nd leg) | PAOK Saloniki | - | AEL Kalloni | 3:0 (0:0) | ||
| 1st(1st leg): 06/01/2016 17:30 | 2nd (2nd leg): 14/01/2016 15:15 | Winner: PAOK Saloniki | ||||
| 1st(1st leg) | PAS Giannina | - | Panathinaikos | 1:2 (0:0) | ||
| 2nd (2nd leg) | Panathinaikos | - | PAS Giannina | 0:1 (0:0) | ||
| 1st(1st leg): 07/01/2016 13:00 | 2nd (2nd leg): 14/01/2016 17:30 | Winner: Panathinaikos | ||||
| 1st(1st leg) | AO Chania | - | Olympiakos Piraeus | 1:4 (1:2) | ||
| 2nd (2nd leg) | Olympiakos Piraeus | - | AO Chania | 6:0 (4:0) | ||
| 1st(1st leg): 07/01/2016 15:15 | 2nd (2nd leg): 13/01/2016 17:30 | Winner: Olympiakos Piraeus | ||||
