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| 1st(1st leg) | Panetolikos | - | Olympiakos Piraeus | 2:1 (1:1) | ||
| 2nd (2nd leg) | Olympiakos Piraeus | - | Panetolikos | 3:1 (1:0, 2:1) aet | ||
| 1st(1st leg): 19/01/2022 13:00 | 2nd (2nd leg): 09/02/2022 16:00 | Winner: Olympiakos Piraeus | ||||
| 1st(1st leg) | Panathinaikos | - | Anagennisi Karditsa | 4:0 (4:0) | ||
| 2nd (2nd leg) | Anagennisi Karditsa | - | Panathinaikos | 0:1 (0:0) | ||
| 1st(1st leg): 19/01/2022 15:00 | 2nd (2nd leg): 09/02/2022 14:00 | Winner: Panathinaikos | ||||
| 1st(1st leg) | PAOK Saloniki | - | AEK Athen | 0:0 (0:0) | ||
| 2nd (2nd leg) | AEK Athen | - | PAOK Saloniki | 1:2 (0:0) | ||
| 1st(1st leg): 19/01/2022 17:00 | 2nd (2nd leg): 09/02/2022 18:00 | Winner: PAOK Saloniki | ||||
| 1st(1st leg) | Aris Saloniki | - | Lamia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Lamia | - | Aris Saloniki | 1:0 (0:0, 0:0) aet | ||
| 1st(1st leg): 20/01/2022 19:30 | 2nd (2nd leg): 26/01/2022 18:00 | Winner: Lamia | ||||
