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| 1st(1st leg) | Iztapa | - | Comunicaciones | 2:2 (0:1) | ||
| 2nd (2nd leg) | Comunicaciones | - | Iztapa | 1:1 (0:1) | ||
| 1st(1st leg): 12/05/2021 19:00 | 2nd (2nd leg): 16/05/2021 01:00 | Winner: Comunicaciones | ||||
| 1st(1st leg) | Santa Lucía | - | Deportivo Guastatoya | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Guastatoya | - | Santa Lucía | 1:2 (1:1) | ||
| 1st(1st leg): 14/05/2021 18:00 | 2nd (2nd leg): 16/05/2021 22:00 | Winner: Santa Lucía | ||||
