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| 1st(1st leg) | Motagua | - | Real España | 1:0 (1:0) | ||
| 2nd (2nd leg) | Real España | - | Motagua | 6:7 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 10/05/2021 00:00 | 2nd (2nd leg): 13/05/2021 01:00 | Winner: Motagua | ||||
| 1st(1st leg) | Honduras Progreso | - | Olimpia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Olimpia | - | Honduras Progreso | 7:0 (3:0) | ||
| 1st(1st leg): 10/05/2021 02:00 | 2nd (2nd leg): 13/05/2021 02:00 | Winner: Olimpia | ||||
