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| 1st(1st leg) | Lobos UPNFM | - | Honduras Progreso | 3:2 (2:1) | ||
| 2nd (2nd leg) | Honduras Progreso | - | Lobos UPNFM | 4:0 (1:0) | ||
| 1st(1st leg): 02/05/2021 00:00 | 2nd (2nd leg): 06/05/2021 02:00 | Winner: Honduras Progreso | ||||
| 1st(1st leg) | Vida | - | Motagua | 1:1 (0:0) | ||
| 2nd (2nd leg) | Motagua | - | Vida | 3:0 (0:0) | ||
| 1st(1st leg): 02/05/2021 22:06 | 2nd (2nd leg): 05/05/2021 02:00 | Winner: Motagua | ||||
