1st(1st leg) AC Milan - Atalanta 4:2
2nd (2nd leg) Atalanta - AC Milan 2:1
1st(1st leg): 28/11/2000 20:00 2nd (2nd leg): 13/12/2000 20:00 Winner: AC Milan
1st(1st leg) Lazio Roma - Udinese Calcio 2:1
2nd (2nd leg) Udinese Calcio - Lazio Roma 4:1
1st(1st leg): 29/11/2000 17:45 2nd (2nd leg): 12/12/2000 20:00 Winner: Udinese Calcio
1st(1st leg) Parma AC - Inter 6:1
2nd (2nd leg) Inter - Parma AC 0:0
1st(1st leg): 29/11/2000 19:45 2nd (2nd leg): 14/12/2000 20:00 Winner: Parma AC
1st(1st leg) ACF Fiorentina - Brescia Calcio 6:0
2nd (2nd leg) Brescia Calcio - ACF Fiorentina 3:1
1st(1st leg): 30/11/2000 20:00 2nd (2nd leg): 13/12/2000 17:30 Winner: ACF Fiorentina