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| 1st(1st leg) | AC Milan | - | Brescia Calcio | 3:1 (2:0) | ||
| 2nd (2nd leg) | Brescia Calcio | - | AC Milan | 3:4 (1:2) | ||
| 1st(1st leg): 29/11/2005 20:05 | 2nd (2nd leg): 11/01/2006 20:00 | Winner: AC Milan | ||||
| 1st(1st leg) | Atalanta | - | Udinese Calcio | 1:0 (0:0) | ||
| 2nd (2nd leg) | Udinese Calcio | - | Atalanta | 3:1 (1:0) | ||
| 1st(1st leg): 30/11/2005 17:05 | 2nd (2nd leg): 11/01/2006 16:30 | Winner: Udinese Calcio | ||||
| 1st(1st leg) | Parma FC | - | Inter | 0:1 (0:0) | ||
| 2nd (2nd leg) | Inter | - | Parma FC | 0:0 (0:0) | ||
| 1st(1st leg): 30/11/2005 20:05 | 2nd (2nd leg): 12/01/2006 20:00 | Winner: Inter | ||||
| 1st(1st leg) | ACF Fiorentina | - | Juventus | 2:2 (1:0) | ||
| 2nd (2nd leg) | Juventus | - | ACF Fiorentina | 4:1 (3:0) | ||
| 1st(1st leg): 01/12/2005 20:05 | 2nd (2nd leg): 10/01/2006 20:00 | Winner: Juventus | ||||
| 1st(1st leg) | AS Bari | - | US Palermo | 0:0 (0:0) | ||
| 2nd (2nd leg) | US Palermo | - | AS Bari | 5:4 (2:1) | ||
| 1st(1st leg): 07/12/2005 17:00 | 2nd (2nd leg): 10/01/2006 14:00 | Winner: US Palermo | ||||
| 1st(1st leg) | Lazio Roma | - | AS Cittadella | 2:0 (1:0) | ||
| 2nd (2nd leg) | AS Cittadella | - | Lazio Roma | 0:0 (0:0) | ||
| 1st(1st leg): 08/12/2005 14:00 | 2nd (2nd leg): 12/01/2006 14:30 | Winner: Lazio Roma | ||||
| 1st(1st leg) | SSC Napoli | - | AS Roma | 0:3 (0:2) | ||
| 2nd (2nd leg) | AS Roma | - | SSC Napoli | 2:1 (2:0) | ||
| 1st(1st leg): 08/12/2005 14:00 | 2nd (2nd leg): 11/01/2006 16:00 | Winner: AS Roma | ||||
| 1st(1st leg) | Cagliari Calcio | - | Sampdoria | 1:1 (0:0) | ||
| 2nd (2nd leg) | Sampdoria | - | Cagliari Calcio | 2:1 (0:0) | ||
| 1st(1st leg): 08/12/2005 17:00 | 2nd (2nd leg): 11/01/2006 19:30 | Winner: Sampdoria | ||||
