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| 1st(1st leg) | Fermana FC | - | Viterbese | 1:0 (0:0) | ||
| 2nd (2nd leg) | Viterbese | - | Fermana FC | 2:0 (1:0) | ||
| 1st(1st leg): 07/05/2022 16:30 | 2nd (2nd leg): 14/05/2022 16:30 | Winner: Viterbese | ||||
| 1st(1st leg) | US Pistoiese | - | Imolese Calcio | 2:1 (0:1) | ||
| 2nd (2nd leg) | Imolese Calcio | - | US Pistoiese | 1:0 (0:0) | ||
| 1st(1st leg): 07/05/2022 17:00 | 2nd (2nd leg): 15/05/2022 17:00 | Winner: Imolese Calcio | ||||
