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| 1st(1st leg) | US Triestina | - | Palermo FC | 1:2 (0:2) | ||
| 2nd (2nd leg) | Palermo FC | - | US Triestina | 1:1 (0:0) | ||
| 1st(1st leg): 08/05/2022 16:30 | 2nd (2nd leg): 12/05/2022 19:30 | Winner: Palermo FC | ||||
| 1st(1st leg) | Foggia Calcio | - | Virtus Entella | 1:0 (0:0) | ||
| 2nd (2nd leg) | Virtus Entella | - | Foggia Calcio | 2:1 (1:0) | ||
| 1st(1st leg): 08/05/2022 17:00 | 2nd (2nd leg): 12/05/2022 19:30 | Winner: Foggia Calcio | ||||
| 1st(1st leg) | Juventus II | - | AC Renate | 1:1 (1:1) | ||
| 2nd (2nd leg) | AC Renate | - | Juventus II | 0:1 (0:1) | ||
| 1st(1st leg): 08/05/2022 17:00 | 2nd (2nd leg): 12/05/2022 19:30 | Winner: Juventus II | ||||
| 1st(1st leg) | Delfino Pescara | - | FeralpiSalò | 3:3 (1:1) | ||
| 2nd (2nd leg) | FeralpiSalò | - | Delfino Pescara | 2:1 (0:0) | ||
| 1st(1st leg): 08/05/2022 18:00 | 2nd (2nd leg): 12/05/2022 19:30 | Winner: FeralpiSalò | ||||
| 1st(1st leg) | SS Monopoli 1966 | - | Cesena FC | 1:2 (1:2) | ||
| 2nd (2nd leg) | Cesena FC | - | SS Monopoli 1966 | 0:3 (0:1) | ||
| 1st(1st leg): 08/05/2022 19:00 | 2nd (2nd leg): 12/05/2022 19:45 | Winner: SS Monopoli 1966 | ||||
