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| 1st(1st leg) | FC Olimpia Bălți | - | FC Academia UTM | 2:0 (0:0) | ||
| 2nd (2nd leg) | FC Academia UTM | - | FC Olimpia Bălți | 0:1 (0:1) | ||
| 1st(1st leg): 10/11/2010 12:00 | 2nd (2nd leg): 24/11/2010 11:00 | Winner: FC Olimpia Bălți | ||||
| 1st(1st leg) | FC Iskra-Stal | - | CSCA-Rapid Chişinău | 1:1 (0:0) | ||
| 2nd (2nd leg) | CSCA-Rapid Chişinău | - | FC Iskra-Stal | 0:2 (0:2) | ||
| 1st(1st leg): 10/11/2010 12:00 | 2nd (2nd leg): 24/11/2010 11:00 | Winner: FC Iskra-Stal | ||||
| 1st(1st leg) | FC Tiraspol | - | FC Sheriff | 2:3 (2:1) | ||
| 2nd (2nd leg) | FC Sheriff | - | FC Tiraspol | 2:0 (2:0) | ||
| 1st(1st leg): 10/11/2010 12:00 | 2nd (2nd leg): 24/11/2010 11:00 | Winner: FC Sheriff | ||||
| 1st(1st leg) | FC Cahul 2005 | - | Dacia Chişinău | 0:0 (0:0) | ||
| 2nd (2nd leg) | Dacia Chişinău | - | FC Cahul 2005 | 7:0 (3:0) | ||
| 1st(1st leg): 10/11/2010 12:00 | 2nd (2nd leg): 24/11/2010 16:00 | Winner: Dacia Chişinău | ||||
