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| 1st(1st leg) | Gallos Blancos | - | FC Juárez | 3:2 (1:1) | ||
| 2nd (2nd leg) | FC Juárez | - | Gallos Blancos | 3:1 (1:0) | ||
| 1st(1st leg): 22/01/2020 01:00 | 2nd (2nd leg): 30/01/2020 03:10 | Winner: FC Juárez | ||||
| 1st(1st leg) | Venados FC | - | CF Pachuca | 1:1 (1:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Venados FC | 3:1 (1:0) | ||
| 1st(1st leg): 22/01/2020 01:00 | 2nd (2nd leg): 29/01/2020 01:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | Dorados de Sinaloa | 1:2 (0:1) | ||
| 2nd (2nd leg) | Dorados de Sinaloa | - | Deportivo Guadalajara | 6:5 (0:1, 0:1) pso | ||
| 1st(1st leg): 22/01/2020 03:00 | 2nd (2nd leg): 29/01/2020 03:10 | Winner: Dorados de Sinaloa | ||||
| 1st(1st leg) | Atlético San Luis | - | Club Tijuana | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club Tijuana | - | Atlético San Luis | 1:0 (0:0) | ||
| 1st(1st leg): 22/01/2020 03:00 | 2nd (2nd leg): 29/01/2020 03:10 | Winner: Club Tijuana | ||||
| 1st(1st leg) | Club Celaya | - | CF Monterrey | 3:4 (1:1) | ||
| 2nd (2nd leg) | CF Monterrey | - | Club Celaya | 3:0 (1:0) | ||
| 1st(1st leg): 23/01/2020 01:00 | 2nd (2nd leg): 30/01/2020 03:10 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Cafetaleros de Chiapas | - | Monarcas Morelia | 4:1 (2:1) | ||
| 2nd (2nd leg) | Monarcas Morelia | - | Cafetaleros de Chiapas | 3:2 (2:0, 3:0) pso | ||
| 1st(1st leg): 23/01/2020 01:00 | 2nd (2nd leg): 30/01/2020 01:00 | Winner: Monarcas Morelia | ||||
| 1st(1st leg) | Atlas Guadalajara | - | Deportivo Toluca | 2:1 (2:1) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Atlas Guadalajara | 5:3 (1:1, 3:2) pso | ||
| 1st(1st leg): 23/01/2020 03:00 | 2nd (2nd leg): 29/01/2020 01:00 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Santos Laguna | - | Pumas UNAM | 4:2 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Santos Laguna | 2:1 (1:1) | ||
| 1st(1st leg): 23/01/2020 03:00 | 2nd (2nd leg): 30/01/2020 01:00 | Winner: Santos Laguna | ||||
