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| 1st(1st leg) | CF América | - | UANL Tigres | 0:4 (0:2) | ||
| 2nd (2nd leg) | UANL Tigres | - | CF América | 2:0 (0:0) | ||
| 1st(1st leg): 07/05/2021 16:00 | 2nd (2nd leg): 11/05/2021 02:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Pumas UNAM | - | CF Monterrey | 1:2 (0:2) | ||
| 2nd (2nd leg) | CF Monterrey | - | Pumas UNAM | 2:1 (0:1) | ||
| 1st(1st leg): 07/05/2021 18:00 | 2nd (2nd leg): 11/05/2021 04:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Deportivo Toluca | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Deportivo Toluca | 3:0 (0:0) | ||
| 1st(1st leg): 07/05/2021 22:00 | 2nd (2nd leg): 11/05/2021 00:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | CF Pachuca | - | Atlas Guadalajara | 0:2 (0:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | CF Pachuca | 3:1 (1:0) | ||
| 1st(1st leg): 08/05/2021 00:30 | 2nd (2nd leg): 10/05/2021 22:00 | Winner: Atlas Guadalajara | ||||
